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5349-24-6 Usage

General Description

N-BUTYL-2-CHLORO-ACETAMIDE is a chemical compound with the molecular formula C6H12ClNO. It is an amide derivative that contains a butyl group and a chloro group attached to the acetamide functional group. N-BUTYL-2-CHLORO-ACETAMIDE is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is also utilized as a reactant in organic synthesis and as a solvent in various chemical processes. N-BUTYL-2-CHLORO-ACETAMIDE is known for its mild odor and is typically stored and handled in accordance with standard safety practices for handling organic chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 5349-24-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,4 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 5349-24:
96 % 10 = 6
So 5349-24-6 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name N-butyl-2-chloroacetamide

1.2 Other means of identification

Product number -
Other names n-butyl chloroacetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5349-24-6 SDS

5349-24-6Relevant articles and documents

Effect on pKa of metal-bound water molecules in lanthanide ion-induced cyclen "cavities"

Gunnlaugsson, Thorfinnur,Brougham, Dermot F.,Fanning, Ann-Marie,Nieuwenhuyzen, Mark,O'Brien, John E.,Viguier, Romain

, p. 4805 - 4808 (2004)

(Chemical Equation Presented) The macrocyclic cyclen conjugates 1-4 were synthesized with the aim of forming lanthanide ion-based macrocyclic conjugates possessing deep cavities, formed upon complexation to various lanthanide ions. These complexes all possess metal-bound water molecules, where the pK a of the water molecules depends on the nature of the cavity.

Sequence-Defined Dithiocarbamate Oligomers via a Scalable, Support-free, Iterative Strategy

Nanjan, Pandurangan,Jose, Anna,Thurakkal, Liya,Porel, Mintu

, p. 11019 - 11026 (2020/12/22)

Precise control over the monomeric sequence on natural sequence-defined polymers (SDPs) leads to their structural diversity and functions. However, absolute control over the monomeric sequence on a synthetic polymer remains a challenging process. Herein, we describe a support-free, protection-deprotection-free, cost-effective, and fast iterative strategy for multigram production of a new class of SDP with a unique functional group, dithiocarbamate, a potential group for material and biomedical applications. The strategy is based on a unique monomer, named as amine-hydroxyl monomer, and a three-component reaction between the monomer, CS2, and terminal chloro group of the growing chain. The fast strategy allows us to synthesize a 5-mer sequence-defined oligomer in 6 h. For a proof of concept, a range of aliphatic and aromatic groups have been incorporated at different sequences in the sequence-defined oligomer. This SDP platform has further been advanced by two ways: (i) multiple approaches for postsynthetic modification of SDP and (ii) increasing the chain length in a single step.

Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy

Sonawane, Vinay,Mohd Siddique, Mohd Usman,Jadav, Surender Singh,Sinha, Barij Nayan,Jayaprakash, Venkatesan,Chaudhuri, Bhabatosh

, p. 115 - 132 (2019/01/23)

Inhibition of cyclin dependent kinase 4 (Cdk4) prevents cancer cells from entering the early G0/G1 phase of the cell division cycle whereas inhibiting tubulin polymerization blocks cancer cells’ ability to undergo mitosis (M) late in the cell cycle. We had reported earlier that two non-planar and relatively non-toxic fascaplysin derivatives, an indole and a tryptoline, inhibit Cdk4 with IC50 values of 6.2 and 10 μM, respectively. Serendipitously, we had also found that they inhibited tubulin polymerization. The molecules were efficacious in mouse tumor models. We have now identified Cink4T in a 59-compound quinazolinone library, designed on the basis of ligand-based virtual screening, as a compound that inhibits Cdk4 and tubulin. Its IC50 value for Cdk4 inhibition is 0.47 μM and >50 μM for inhibition of Cdk1, Cdk2, Cdk6, Cdk9. Cink4T inhibits tubulin polymerization with an IC50 of 0.6 μM. Molecular modelling studies on Cink4T with Cdk4 and tubulin crystal structures lend support to these observations. Cancer cell cycle analyses confirm that Cink4T blocks cells at both G0/G1 and M phases as it should if it were to inhibit both Cdk4 and tubulin polymerization. Our results show, for the very first time, that virtual screening can be used to design novel inhibitors that can potently block two crucial phases of the cell division cycle.

Synthesis of E/Z N-(1-Chlorovinyl)formamide Using Vilsmeier–Haack Reaction

Tang, Linlin,Wang, Jingtao,Xia, Xiaojiao,Zuo, Hua,Choi, Kyung-Min,Shin, Dong-Soo

supporting information, p. 243 - 247 (2019/03/14)

Synthesis of a variety of novel Z/E N-(1-chlorovinyl)formamides through Vilsmeier–Haack reaction starting from 2-phenoxyethanamides with POCl3/DMF has been accomplished. The reactions introduced chlorine atom to the Cα-position and p

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