5349-55-3Relevant academic research and scientific papers
Ni-Catalyzed C(sp3)–O Arylation of α-Hydroxy Esters
Monteith, John J.,Rousseaux, Sophie A. L.
supporting information, p. 9485 - 9489 (2021/12/09)
A Negishi cross-coupling of α-hydroxy ester derivatives and arylzinc reagents has been developed. This reaction tolerates both primary and secondary C(sp3)–O alcohol precursors and achieves efficient cross-coupling under Ni catalysis without the need for added external metal reductant, photocatalyst, or additives. The arylation of readily accessible C(sp3)–O electrophiles in this operationally simple, rapid, and mild reaction provides a complementary way of accessing desirable α-aryl ester products.
Autoxidation of Allyl Ether Compounds. Part 1. Reactivity of Allyl Ether Alcohols.
Toivonen, Hannu
, p. 37 - 42 (2007/10/02)
Cobalt catalyzed liquid phase autoxidations of some primary and secondary allyl ether alcohols were studied at 30 and 40 deg C.An optimum concentration for the catalyst was found, above which cobalt behaved like an inhibitor.Autoxidations of secondary allyl ether alcohols started immediately after adding the catalyst but the reactions of the allyl ethers of primary diols were preceded by induction periods.Induction periods depended on the carbon chain length of the diol and were not observed after methylating the hydroxyl group of the allyl ether alcohol.The phenomena are explained as resulting from inter- and intramolecular hydrogen bonding, which controls the autoxidation by decreasing the electron density on the etheral oxygen.
