53498-64-9

Usage

Uses

Used in Chemical Reactions:
2-methyl-2-(3-methylphenoxy)propanoic acid is used as a reagent for various chemical reactions due to its unique structure and properties. Its benzene ring and carboxylic acid groups allow it to participate in a wide range of reactions, making it a valuable compound in the field of organic chemistry.
Used in Pharmaceutical Industry:
2-methyl-2-(3-methylphenoxy)propanoic acid is used as an intermediate in the synthesis of pharmaceutical compounds. Its structural features enable it to be a key component in the development of new drugs, potentially leading to advancements in medicine.
Used in Material Science:
2-methyl-2-(3-methylphenoxy)propanoic acid is used as a building block in the creation of new materials. Its chemical properties allow it to be incorporated into the design of novel materials with unique characteristics, such as improved strength or enhanced chemical resistance.
Used in Research and Development:
2-methyl-2-(3-methylphenoxy)propanoic acid is used as a research compound for studying its properties and potential applications. Scientists and researchers utilize 2-methyl-2-(3-methylphenoxy)propanoic acid to explore its reactivity, stability, and interactions with other chemicals, which can lead to new discoveries and innovations in the field of chemistry.

InChI:InChI=1/C11H14O3/c1-8-5-4-6-9(7-8)14-11(2,3)10(12)13/h4-7H,1-3H3,(H,12,13)

Upstream product

• 67-66-3 chloroform 
• 108-39-4 3-methyl-phenol 
• 67-64-1 acetone 
• 3019-89-4 sodium 3-methylphenoxide 
• 2052-01-9 2-bromo-2-methylpropionic acid 
• 64416-94-0 2-methyl-2-m-tolyloxypropionic acid ethyl ester 

Downstream Products

• 124237-26-9 α-(3-methylphenoxy)isobutyric acid hydrazide 
• 63294-13-3 2-(3-methylphenoxy)-2-methylpropionyl chloride 
• 124237-27-0 1-(3'-methylphenoxyisobutyramido)-2,5-dimethylpyrrole 
• 78613-25-9 2-amino-5-(3'-methylphenoxyisopropyl)-1,3,4-oxadiazole 

Relevant academic research and scientific papers

The formation of benzoxacin-3-ones: Via intramolecular Nicholas reactions and synthesis of 8-membered heliannuols

The γ-carbonyl cations generated from propargyl ether-Co2(CO)6 complexes undergo intramolecular Nicholas reactions to give dehydrobenzoxacin-3-one-Co2(CO)6 complexes in good yields. Reductive decomplexation and subsequent manipulation allows the synthesis of (±)-heliannuol K methyl ether and the formal syntheses of (±)-heliannuol K, (±)-heliannuol A, and (-)-heliannuol L.

Pd(II)-catalyzed ortho - Or meta-C-H olefination of phenol derivatives

A combination of weakly coordinating auxiliaries and ligand acceleration allows for the development of both ortho- and meta-selective C-H olefination of phenol derivatives. These reactions demonstrate the feasibility of directing C-H functionalizations when functional groups are distal to target C-H bonds. The meta-C-H functionalization of electron-rich phenol derivatives is unprecedented and orthogonal to previous electrophilic substitution of phenols in terms of regioselectivity. These methods are also applied to functionalize α-phenoxyacetic acids, a fibrate class of drug scaffolds.

Synthesis and preliminary antihyperlipidaemic activities evaluation of andrographolide derivatives

Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.

Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives

Novel 2-substituted isobutyric acid derivatives were synthesized and their hypolipidemic activity was evaluated in high cholesterol diet fed rat model. The amide 5a was found to decrease the levels of serum total cholesterol, LDL cholesterol and triglycer