5350-76-5

Basic information

• Product Name: 1-phenyl-2-(2,4,6-trimethylphenyl)ethanone
• CAS NO: 5350-76-5
• Molecular Formula: C₁₇H₁₈O
• Molecular Weight: 238.3242
• Mol File: 5350-76-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 372.7°C at 760 mmHg
• Flash Point: 160.8°C
• Density: 1.033g/cm³
• Vapor Pressure: 9.43E-06mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: 1-phenyl-2-(2,4,6-trimethylphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-2-(2,4,6-trimethylphenyl)ethanone(5350-76-5)
• EPA Substance Registry System: 1-phenyl-2-(2,4,6-trimethylphenyl)ethanone(5350-76-5)

Safety Data

• Hazardous Substances Data: 5350-76-5(Hazardous Substances Data)

Usage

Class

Ketones

Functional groups

Aromatic and ketone

Physical state

Colorless to pale yellow liquid

Odor

Strong, sweet, and floral

Uses

Organic synthesis, production of fragrances, flavorings, and other aromatics, solvent in some applications.

Upstream product

• 34688-71-6 mesitylacetonitrile 
• 52629-46-6 (2,4,6-trimethyl-phenyl)acetyl chloride 
• 591-51-5 phenyllithium 
• 25056-07-9 1-Phenyl-2-(2,4,6-trimethyl-phenyl)-ethane-1,2-dione 
• 64-19-7 acetic acid 
• 7664-93-9 sulfuric acid 
• 149603-31-6 1-phenyl-2-mesityl-ethanediol-(1,2) 
• 84840-80-2 (p-methoxyphenyl)phenacyllead diacetate 
• 84840-85-7 (p-methoxyphenyl)-α-methylphenacyllead diacetate 
• 50447-68-2 2-(2,4,6-trimethylphenyl)oxirane 
• 17763-67-6 Phenyl triflate 
• 29778-31-2 1-(phenylethynyl)-2,4,6-trimethylbenzene 
• 4408-60-0 2-mesitylacetic acid 
• 20797-56-2 2,4,6-trimethylmandelic acid 

Downstream Products

• 139545-55-4 2-(2,4,6-Trimethylphenyl)-1-phenylpropenon 
• 855242-29-4 1,4-dimesityl-2,3-diphenyl-butane-2,3-diol 
• 25056-07-9 1-Phenyl-2-(2,4,6-trimethyl-phenyl)-ethane-1,2-dione 
• 84839-90-7 1-phenyl-2-(2',4',6'-trimethylphenyl)propan-1-one 
• 3901-04-0 α-mesityl-α-phenylacetic acid 
• 25056-06-8 2-hydroxy-1-mesityl-2-phenylethanone 
• 1889-82-3 2-hydroxy-1-mesityl-2,2-diphenyl-ethanone 
• 109404-66-2 2',4',6'-Trimethyl-benzoin 
• 107773-78-4 2,4,6-trimethyl-benzilic acid 
• 92345-73-8 α-mesitylacetophenone ketazine 
• 92345-79-4 1-(1-phenyl-2-mesitylethenyl)-4-(2-mesitylethenyl)benzene 
• 92345-70-5 N-(1-phenyl-2-mesitylethyl)acetamide 
• 92345-68-1 1-phenyl-2-mesityldiazoethane 
• 92345-72-7 1-Phenyl-2-(2,4,6-trimethyl-phenyl)-ethylamine 

Relevant articles and documents

Preparation method of aryl ketone

The invention discloses a preparation method of aryl ketone. The preparation method comprises the following steps: mixing a phenyl epoxy compound, aryl trifluoromethanesulfonate, a phosphine ligand, a nickel source, alkali and an organic solvent, and conducting reacting in one step under the protection of inert gas to generate aryl ketone. The preparation method disclosed by the invention is simple in process, mild in conditions and low in cost, and paves a way for large-scale industrial production application, such as drug synthesis or natural product synthesis application, of aryl ketone serving as an important organic reaction intermediate.

Heck reactions of α- or β-substituted enol ethers with aryl bromides catalysed by a tetraphosphane/palladium complex - Direct access to acetophenone or 1-arylpropanone derivatives

cis,cis,cis-1,2,3,4-Tetrakis(diphenylphosphanylmethyl)cyclopentane/ [PdCl(C3H5)]2 efficiently catalyses the Heck reaction of α- and β-substituted enol ethers with aryl bromides. The arylation of 1-phenyl-1-(trimethylsilyloxy) ethylene led directly to the 2-aryl-1-phenylethanones. Similar reaction rates were observed with electron-rich, electron-deficient or sterically congested aryl bromides. Heck reaction with benzyl isopropenyl ether gave a mixture of isomers. However, this mixture gave selectively the 1-arylpropanones after hydrolysis. Employing β-methoxystyrene, 3-ethoxyacrylonitrile or methyl 3-methoxyacrylate, the regioselective α-arylation of these enol ethers was observed in all cases, but mixtures of (Z) and (E) isomers were generally obtained, which in many cases yielded a single ketone product after acid treatment. The stereoselectivity of this reaction depends on steric and electronic factors, and better stereoselectivities in favour of (Z) isomers were observed with electron-rich or sterically congested aryl bromides. Higher yields were obtained for this reaction with electron-rich or sterically congested aryl bromides than with electron-poor aryl bromides. These observations suggest that the rate-limiting step of the catalytic cycle is not the oxidative addition of the aryl bromide to the palladium complex with these substituted enol ethers. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

DURCH STERISCHE EFFEKTE STABILISIERTE β-KETOCARBONSAEUREN

Increasing steric hindrance in β-keto carboxylic acids leads to an increasing kinetic stability towards decarboxylation, till systems are reached wich are completely stable at room temperature.Simultaneously the tautomeric equilibrium is changed in favour of the (Z)-enol, and finally in favour of the (E)-configurated enol.