53500-88-2

Upstream product

• 38861-78-8 1-(4-isobutyl-phenyl)-ethanone 
• 96-34-4 methyl chloroacetate 
• 67-56-1 methanol 
• 58901-83-0 3-methyl-3-(p-isobutylphenyl)glycidonitrile 

Downstream Products

• 54017-14-0 methyl 3-methyl-3-(4-isobutylphenyl)-pyruvate 
• 53600-17-2 methyl 2-hydroxy-3-(4-isobutylphenyl)-3-butenoate 

Relevant academic research and scientific papers

REACTION OF 4-SUBSTITUTED BENZALDEHYDES AND ACETOPHENONES WITH CHLOROACETONITRILE

Under conditions of phase-transfer catalysis or in homogeneous solution of potassium tert-butoxide the title compounds give stereoisomeric mixtures of substituted 2,3-epoxy nitriles III and IV.Alkaline hydrolysis of epoxy nitriles IV afforded the corresponding 2-arylpropanals in low yields.On treatment with methanol and potassium carbonate, epoxy nitriles III and IV were converted into epoxy esters in good yields.

Butenoic and pyruvic acid derivatives

Process for preparing a 2-hydroxy-butenoic acid derivative of the general formula, STR1 wherein R1 is a group selected from aliphatic, alicyclic or aromatic radicals and R2 is a lower alkyl group by heating a glycidic acid derivative

Process for producing 2-hydroxy-3-butenoic acid derivatives

Process for producing a 2-hydroxy-3-butenoic acid derivative having the formula STR1 wherein R1 is an aliphatic, alicyclic or aromatic group and R2 is a lower alkyl group by treating a glycidic acid ester derivative having the formul

2-Hydroxy-3(4-alkylphenyl)-3-butenoic acid ester and process for the production thereof

A new process for the production of a 2-(4-alkylphenyl)-propionic acid known as a valuable anti-inflammatory agent is now provided, which comprises treating an alkyl 2-hydroxy-3-(4-alkylphenyl)-3-butenoate, a new compound, with an alkali metal alcoholate in an alcohol to give the corresponding alkyl 3-methyl-3-(4-alkylphenyl)-pyruvate, also a new compound, which is then hydrolysed to liberate the corresponding 3-methyl-3-(4-alkylphenyl)-pyruvic acid, and then oxidising the liberated pyruvic acid compound to the desired 2-(4-alkylphenyl)-propionic acid. This new process is operable in a facile way with a high yield of the desired product and is much suitable for a commercial practice than the prior art methods.