58901-83-0Relevant academic research and scientific papers
REACTION OF 4-SUBSTITUTED BENZALDEHYDES AND ACETOPHENONES WITH CHLOROACETONITRILE
Svoboda, Jiri,Kocfeldova, Zuzana,Palecek, Jaroslav
, p. 822 - 832 (2007/10/02)
Under conditions of phase-transfer catalysis or in homogeneous solution of potassium tert-butoxide the title compounds give stereoisomeric mixtures of substituted 2,3-epoxy nitriles III and IV.Alkaline hydrolysis of epoxy nitriles IV afforded the corresponding 2-arylpropanals in low yields.On treatment with methanol and potassium carbonate, epoxy nitriles III and IV were converted into epoxy esters in good yields.
Preparing carboxylic acids from glycidonitriles through enol acylates
-
, (2008/06/13)
Process for preparing carboxylic acids by converting a glycidonitrile to the enol acylate via hydrohalogenation, acylation and dehydrohalogenation procedures, and conversion of the enol acylate to the carboxylate salt with a base and of the salt to the carboxylic acid with acid. Cyanide content in the mixture is destroyed by adding persulfate or hypochlorite salts. This process, can be used, e.g., to prepare 2-(4'-isobutylphenyl)propionic acid, now known generically as ibuprofen, a highly active anti-inflammatory drug, as well as a host of other useful carboxylic acids.
Process for preparing glycidonitriles
-
, (2008/06/13)
Process for preparing glycidonitriles in which a ketone or aldehyde is reacted with chloroacetonitrile under substantially anhydrous conditions using inorganic alkali metal bases in a solvent medium containing at least about 3 percent liquid volume of a dipolar, aprotic liquid such as dimethylformamide, any balance of solvent being a nonpolar organic liquid.
