5351-58-6

Basic information

• Product Name: Carbohydrazide, 1-benzylidene-3-thio-
• CAS NO: 5351-58-6
• Molecular Formula: C₈H₁₀N₄S
• Molecular Weight: 194.26
• Mol File: 5351-58-6.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Carbohydrazide, 1-benzylidene-3-thio-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbohydrazide, 1-benzylidene-3-thio-(5351-58-6)
• EPA Substance Registry System: Carbohydrazide, 1-benzylidene-3-thio-(5351-58-6)

Safety Data

• Hazardous Substances Data: 5351-58-6(Hazardous Substances Data)

Upstream product

• 6956-33-8 dibenzylidenethiocarbohydrazide 
• 26151-92-8 S-ethyl-β-N-(benzylidene)dithiocarbazate 
• 130822-37-6 4-acetyl-2-(1'-acetyl-2'-benzylidene)hydrazino-5-phenyl-4,5-dihydro-1,3,4-thiadiazole 
• 100-52-7 benzaldehyde 
• 2231-57-4 Thiocarbohydrazide 

Downstream Products

• 111562-39-1 3-benzylidenehydrazino-5-methyl-1⁽²⁾H-pyrazole-4-carboxylic acid ethyl ester 
• 109500-72-3 3-amino-2-benzylidenehydrazono-4-methyl-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester 
• 35541-19-6 β-isatin benzaldehyde thiocarbohydrazone 
• 1009831-71-3 1-[N'-(phenylmethylene)carbothiohydrazinoyl]-5-hydroxy-3-phenyl-5-(2-thienyl)-2-pyrazoline 
• 1009831-69-9 1-[N'-(phenylmethylene)carbothiohydrazinoyl]-5-hydroxy-3,5-diphenyl-2-pyrazoline 
• 1132880-97-7 benzaldehyde N'-(5-benzoylmethyl-1,3,4-thiadiazol-2-yl)hydrazone hydrobromide 
• 1243671-62-6 5,5'-bis-[N-benzylidene-N'-(3-phenyl-3H-[1,3,4]thiadiazol-2-ylidene)hydrazine] 
• 1243671-63-7 2'-(4-nitrophenylmethylene)-2-(phenylenemethylene)carbonothioic dihydrazide 
• 1243671-60-4 N-benzylidene-N'-[3-(4-nitrophenyl)-5-pyridin-2-yl-3H-[1,3,4]thiadiazol-2-ylidene]hydrazine 
• 1243671-59-1 N-benzylidene-N'-[3-(4-nitrophenyl)-5-thiophen-2-yl-3H-[1,3,4]thiadiazol-2-ylidene]hydrazine 
• 1243671-57-9 N-benzylidene-N'-[5-furan-2-yl-3-(4-nitrophenyl)-3H-[1,3,4]thiadiazol-2-ylidene]hydrazine 
• 1243671-51-3 N-benzylidene-N'-[3-(4-nitro-phenyl)-5-p-tolyl-3H-[1,3,4]thiadiazol-2-ylidene]hydrazine 
• 1243671-54-6 N-benzylidene-N'-[5-(4-fluorophenyl)-3-(4-nitrophenyl)-3H-[1,3,4]thiadiazol-2-ylidene]hydrazine 
• 1243671-55-7 N-benzylidene-N'-[5-(4-chlorophenyl)-3-(4-nitrophenyl)-3H-[1,3,4]thiadiazol-2-ylidene]hydrazine 

Relevant articles and documents

Preparation, characterization, antioxidant properties of novel Schiff bases including 5-chloroisatin-thiocarbohydrazone

Thanks to its pharmaceutical properties, the Schiff group of isatin has recently had a wide range of uses. In this study, seven new Schiff bases of isatin and its derivatives were prepared from thiocarbohydrazide, isatin and substituted aldehydes in the presence of ethanol under reflux. The chemical structures of the products were confirmed by 1H NMR, 13C NMR, IR and elemental analysis. The in vitro antioxidant features of all the compounds were evaluated by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging method. The antioxidant effect was evaluated separately in two different stages: monosubstituted products synthesized with aldehyde groups and disubstituted products bound with isatin group. Accordingly, the compounds 3 and 4 showed the highest antioxidant activity and the isatin group suppressed the antioxidant effect of the disubstituted Schiff bases products.

The Reaction of Phosphorus Decasulfide with some Hydrazides and their Hydrazones: New Route for Construction of Four-membered, Five-membered, and Six-membered Phosphorus Heterocycles

Reaction of some selected benzoic acid hydrazides 1a–c with phosphorus decasulfide P4S10 in dry pyridine afforded some novel pyridine solvate of 1,3,4,2-thiadiazaphospholes 2a–c. Similarly, treatment of their corresponding hydrazones 3a–c toward phosphorus decasulfide under the same reaction conditions gave the corresponding thio-analog 4 and 1,3,2-benzoxazaphosphinine and benzodiazaphosphinine pyridine solvates 5a,b, respectively. Treatment of (thio)semicarbazides and their corresponding (thio)semicarbazones with phosphorus decasulfide in dry pyridine yielded the novel 1,2,4,3-triazaphospholidines 6a,b, and 1,3,2-diazaphosphetidines 8a,b, respectively. Moreover, cyclization of (thio)carbohydrazides and their mono-(thio)carbohydrazones with phosphorus decasulfide produced 1,2,4,3-triazaphospholidines 9a,b and 11a,b, respectively. The structures of these products were confirmed from analytical and spectral data.

Microwave-assisted synthesis and antibacterial activity of unsymmetrical indolyl/aryl bis-thiosemicarbazones

A series of nine novel unsymmetrical bis-thiosemicarbazones were prepared in high yield by condensation of aromatic aldehyde thiosemicarbazones with indole-3-carboxaldehyde using microwave irradiation. The structures of the new compounds were characterised. Six of the compounds displayed varying levels of antibacterial activity against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus.