5351-70-2

Basic information

• Product Name: Cinnamaldehyde thiosemicarbazone
• Synonyms: 1-(3-Phenyl-2-propenylidene)thiosemicarbazide;1-(3-Phenylallylidene)thiosemicarbazide;3-Phenylpropenalthiosemicarbazone;3-phenylacrylaldehyde thiosemicarbazone;[(E)-[(E)-3-phenylprop-2-enylidene]amino]thiourea
• CAS NO: 5351-70-2
• Molecular Formula: C₁₀H₁₁N₃S
• Molecular Weight: 205.28
• Mol File: 5351-70-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 139 °C
• Boiling Point: 363°Cat760mmHg
• Flash Point: 173.3°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 1.86E-05mmHg at 25°C
• Refractive Index: 1.598
• PKA: 11.61±0.70(Predicted)
• CAS DataBase Reference: Cinnamaldehyde thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: Cinnamaldehyde thiosemicarbazone(5351-70-2)
• EPA Substance Registry System: Cinnamaldehyde thiosemicarbazone(5351-70-2)

Safety Data

• Hazardous Substances Data: 5351-70-2(Hazardous Substances Data)

Usage

General Description

Cinnamaldehyde thiosemicarbazone is a chemical compound that is derived from cinnamaldehyde, which is found in cinnamon oil. It is a thiosemicarbazone derivative, meaning it contains a sulfur atom in its structure. Cinnamaldehyde thiosemicarbazone has been studied for its potential biological activities, including its antimicrobial, antitumor, antiviral, and antioxidant properties. It has also been investigated for its potential use in the development of new drugs for the treatment of various diseases. Cinnamaldehyde thiosemicarbazone has shown promising results in laboratory studies, but further research is needed to fully understand its potential applications in medicine and other fields.

InChI:InChI=1/C10H11N3S/c11-10(14)13-12-8-4-7-9-5-2-1-3-6-9/h1-8H,(H3,11,13,14)

Upstream product

• 79-19-6 thiosemicarbazide 
• 104-55-2 3-phenyl-propenal 
• 4346-94-5 thiosemicarbazide hydrochloride 

Downstream Products

• 73923-65-6 2-[5-(4,5-diphenyl-thiazol-2-yl)-3-styryl-formazan-1-yl]-benzoic acid 
• 114554-95-9 [(3-phenyl-2-propenylidene)hydrazono]thiazolidin-4-one 
• 1226451-88-2 Cl₃Sb*C₁₀H₁₁N₃S 
• 618064-77-0 1-(4-(4-methoxyphenyl)thiazol-2-yl)-2-(3-phenylallylidene)hydrazine 
• 357639-18-0 1-(4-(4-bromophenyl)thiazol-2-yl)-2-(3-phenylallylidene)hydrazine 
• 134834-88-1 1-[1-Acetyl-3-(5-nitro-furan-2-ylmethylsulfanyl)-5-((Z)-styryl)-1,5-dihydro-[1,2,4]triazol-4-yl]-ethanone 
• 51680-05-8 5-acetylamino-2-styryl-1,3,4-thiadiazole 
• 73923-56-5 3-phenyl-propenal (4,5-diphenyl-thiazol-2-yl)-hydrazone 
• 151921-24-3 1-allylphenylidene-4-(N-antipyrinyl-glycyl)-3-thiosemicarbazone 
• 134834-80-3 C₁₅H₁₄N₄O₃S*BrH 
• 28004-54-8 2-amino-5-styryl-1,3,4-thiadiazole 

Relevant articles and documents

Design, synthesis, and cytotoxicity screening of new synthesized imidazolidine-2-thiones as VEGFR-2 enzyme inhibitors

A series of imidazolin-2-thione derivatives was synthesized and structurally confirmed through the use of different spectroscopic techniques such as infrared, nuclear magnetic resonance, and mass spectrometry along with elemental analyses. The breast canc

PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles

A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.

Thiosemicarbazones as Aedes aegypti larvicidal

Abstract A set of aryl- and phenoxymethyl-(thio)semicarbazones were synthetized, characterized and biologically evaluated against the larvae of Aedes aegypti (A. egypti), the vector responsible for diseases like Dengue and Yellow Fever. (Q)SAR studies were useful for predicting the activities of the compounds not included to create the QSAR model as well as to predict the features of a new compound with improved activity. Docking studies corroborated experimental evidence of AeSCP-2 as a potential target able to explain the larvicidal properties of its compounds. The trend observed between the in silico Docking scores and the in vitro pLC50 (equals -log LC50, at molar concentration) data indicated that the highest larvicidal compounds, or the compounds with the highest values for pLC50, are usually those with the higher docking scores (i.e., greater in silico affinity for the AeSCP-2 target). Determination of cytotoxicity for these compounds in mammal cells demonstrated that the top larvicide compounds are non-toxic.