53514-41-3

Basic information

• Product Name: 1-Benzoyl-3-(2-hydroxyphenyl)thiourea
• Synonyms: 1-(2-Hydroxyphenyl)-3-benzoylthiourea;1-Benzoyl-3-(2-hydroxyphenyl)thiourea;1-Benzoyl-3-(o-hydroxyphenyl)thiourea;USAF K-1482;3-Benzoyl-1-(o-hydroxyphenyl)-2-thiourea;Brn 3354302;Urea, 1-benzoyl-3-(o-hydroxyphenyl)-2-thio-
• CAS NO: 53514-41-3
• Molecular Formula: C₁₄H₁₂N₂O₂S
• Molecular Weight: 272.3223
• Mol File: 53514-41-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.382g/cm³
• Refractive Index: 1.724
• CAS DataBase Reference: 1-Benzoyl-3-(2-hydroxyphenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzoyl-3-(2-hydroxyphenyl)thiourea(53514-41-3)
• EPA Substance Registry System: 1-Benzoyl-3-(2-hydroxyphenyl)thiourea(53514-41-3)

Safety Data

• Hazardous Substances Data: 53514-41-3(Hazardous Substances Data)

Usage

Structure

Thiourea derivative with a benzoyl group at one end and a 2-hydroxyphenyl group at the other

Pharmaceutical

Inhibitor of protein kinase C and tyrosine kinase

Industrial

Potential anti-tumor agent
c. Antimicrobial and antifungal properties
d. Corrosion inhibitor for metal surfaces

Research and development

Interesting compound for further research in medicinal and material science due to its unique structure and potential biological activities

InChI:InChI=1/C14H12N2O2S/c17-12-9-5-4-8-11(12)15-14(19)16-13(18)10-6-2-1-3-7-10/h1-9,17H,(H2,15,16,18,19)

Upstream product

• 95-55-6 2-amino-phenol 
• 532-55-8 Benzoyl isothiocyanate 
• 1147550-11-5 ammonium thiocyanate 
• 98-88-4 benzoyl chloride 
• 45943-14-4 benzoyl isothiocyanate 

Downstream Products

• 21344-88-7 N-(2-hydroxyphenyl)-4-(4-chlorophenyl)-1,3-thiazole-2-amine 
• 1520-26-9 2-hydroxyphenylthiourea 

Relevant articles and documents

Colorimetric detection of fluoride ions in aqueous medium using thiourea derivatives: A transition metal ion assisted approach

This work explores the position of the hydroxyl moiety and its participation in intramolecular H-bonding towards dictating the fluoride selective colorimetric response in functionalized thiourea derivatives. The study reveals the pivotal aspect of the hyd

Ultrasound promoted synthesis, characterization and computational studies of some thiourea derivatives

Synthesis of some thiourea derivatives have been achieved by using ultrasound, the compounds have been characterised using IR, NMR, GC-MS and elemental analysis. The single crystal X-ray structure of N-[(benzyloxy)methanethioyl]benzamide (IV), 1-benzoyl-3-(2-hydroxyethyl)thiourea (V) and 3-benzoyl-1-(1-benzylpiperidin-4-yl)thiourea (VI) has been presented and the bond lengths and bond angles contrasted with computed results. The HOMO and LUMO energy levels as well as the global chemical reactivity descriptors of the compounds have also been computed and discussed. Two comformers were obtained for compounds IV to VI in the molecular Electrostatic potential and the vibrational frequency computations and these have been discussed.

OPIOID RECEPTOR MODULATORS AND USE THEREOF

Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method