53557-95-2

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 123-11-5 4-methoxy-benzaldehyde 
• 123-54-6 acetylacetone 
• 300-87-8 3,5-dimethyl-1,2-oxazole 

Downstream Products

• 103806-30-0 2-Acetyl-3-(4-methoxy-phenyl)-4-(3-methyl-4-nitro-isoxazol-5-yl)-butyric acid ethyl ester 
• 79510-68-2 5-(4-Methoxy-phenyl)-3'-methyl-4'-nitro-3-phenyl-4,5-dihydro-[4,5']biisoxazolyl 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 79510-61-5 3-[1-(4-Methoxy-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethyl]-pentane-2,4-dione 
• 1021951-87-0 (1R,2S)-1-(4-methoxyphenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane-1,2-diol 
• 53558-02-4 5-(4-methoxy-styryl)-3-methyl-isoxazol-4-ylamine 
• 1229422-27-8 1-(4-methoxyphenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethanesulfonic acid 
• 1314231-02-1 5-(2-benzylsulfanyl-2-(4-methoxyphenyl)ethyl)-3-methyl-4-nitroisoxazole 
• 1426132-30-0 (2'R,3'S,4'S)-1-benzyl-3'-(4-methoxyphenyl)-4'-(3-methyl-4-nitroisoxazol-5-yl)-5'-thioxospiro[indoline-3,2'-pyrrolidin]-2-one 
• 1334145-76-4 (S)-5-(2-(4-methoxyphenyl)-2-(phenylthio)ethyl)-3-methyl-4-nitroisoxazole 

Relevant academic research and scientific papers

Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes

A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.

Tandem grinding reactions involving aldol condensation and Michael addition in sequence for synthesis of 3,4,5-trisubstituted isoxazoles

A one-pot, base-catalyzed, tandem grinding process involving carrying out aldol condensation and Michael addition in sequence to produce 3,4,5-trisubstituted isoxazoles from 3,5-dimethyl-4-nitroisoxazole, aromatic aldehydes and activated methylene compoun

An efficient solvent-free synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using solid nano-titania

Abstract: An efficient and solvent-free procedure for the synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using nano-titania as solid support and recyclable catalyst is presented. This method provides clean, simple, solvent-free and useful alternative to

Catalytic enantioselective addition of isocyanoacetate to 3-methyl-4-nitro-5-styrylisoxazoles under phase transfer catalysis conditions

The reaction between 3-methyl-4-nitro-5-styrylisoxazoles and ethyl isocyanoacetate proceeded under phase transfer catalysis to give enantioenriched monoadducts in high enantiomeric excess (up to 99% ee). The resulting adducts were subsequently cyclised to give 2,3-dihydropyrroles and substituted pyrrolidines in identical high ees and as a single diastereoisomer.

One-pot synthesis of functionalized isoxazole-thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions

One-pot synthesis of highly functionalized tetrahydrothiophene (thiolane) derivatives conjugated with biologically useful isooxazole are reported via the Knoevenagel condensation followed by domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactio

Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam

Highly efficient asymmetric vinylogous 1,6-Michael addition of α,β-unsaturated γ-butyrolactam to 3-methyl-4-nitro-5-alkenyl- isoxazoles and Michael addition to trichloromethyl ketones by using a chiral quinine-derived squaramide organocatalyst were described, giving products with high diastereo- and enantioselectivities (up to >25:1 dr and 96% ee).

Trifluoromethylation of aromatic isoxazoles: Regio- and diastereoselective route to 5-trifluoromethyl-2-isoxazolines

It all adds up: The activation of aromatic isoxazoles with a nitro group at the 4-position has enabled the first regio- and diastereoselective trifluoromethylation at the 5-position of isoxazoles by nucleophilic addition using Me3SiCF3 (see scheme; DMF=N,N′- dimethylformamide). The process was demonstrated with a broad range of 3,5-aromatic, heteroaromatic and aliphatic substrates.

Studies on the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles

We have investigated the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles. This study revealed that the title compounds were optimal Michael acceptors toward thiols. A procedure was also established to prepare isoxazole-containing sul

A fast and highly efficient protocol for synthesis of pyrrolo[2,3-d] isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles using task-specific ionic liquids as catalyst and green solvent

We report a mild, fast, highly efficient and eco-friendly protocol for the green synthesis of pyrrolo[2,3-d]isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles from nitro styrylisoxazoles in SnCl 2-ionic liquid by reductive

Multi-component synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N- oxides

A three component one-pot protocol was investigated for the synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N-oxides from commercially available materials.