53557-96-3

Upstream product

• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 123-54-6 acetylacetone 
• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 104-55-2 3-phenyl-propenal 
• 14371-10-9 (E)-3-phenylpropenal 

Downstream Products

• 1459161-50-2 tert-butyl (2S)-2-((2R,E)-1-(3-methyl-4-nitroisoxazol-5-yl)-4-phenylbut-3-en-2-yl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate 

Relevant academic research and scientific papers

One-pot synthesis of functionalized isoxazole-thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions

One-pot synthesis of highly functionalized tetrahydrothiophene (thiolane) derivatives conjugated with biologically useful isooxazole are reported via the Knoevenagel condensation followed by domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactio

Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam

Highly efficient asymmetric vinylogous 1,6-Michael addition of α,β-unsaturated γ-butyrolactam to 3-methyl-4-nitro-5-alkenyl- isoxazoles and Michael addition to trichloromethyl ketones by using a chiral quinine-derived squaramide organocatalyst were described, giving products with high diastereo- and enantioselectivities (up to >25:1 dr and 96% ee).