53572-98-8

Usage

Uses

Used in Pharmaceutical Industry:
Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid is used as a pharmaceutical agent for its potential anti-inflammatory and anti-cancer properties. Its unique structure allows it to modulate various biological pathways and targets, offering a promising avenue for the development of new therapeutics to combat inflammation and cancer.
Used in Agrochemical Industry:
In the agrochemical field, imidazo[2,1-b][1,3]thiazole-6-carboxylic acid is utilized as a bioactive compound with potential applications in pest control and crop protection. Its ability to exhibit pesticidal properties makes it a candidate for the development of novel agrochemicals that can enhance crop yields and protect against various pests.
Used in Organic Synthesis:
Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid serves as a valuable building block in organic synthesis. Its versatile structure allows for the creation of a wide range of derivative compounds with potential applications in various industries, including the synthesis of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Medicinal Chemistry Research:
As a subject of interest in medicinal chemistry, imidazo[2,1-b][1,3]thiazole-6-carboxylic acid is used in research to explore its potential interactions with biological targets and to understand its mechanisms of action. This research is crucial for the advancement of drug discovery and the development of new therapeutic agents.

InChI:InChI=1/C6H4N2O2S/c9-5(10)4-3-8-1-2-11-6(8)7-4/h1-3H,(H,9,10)/p-1

Upstream product

• 96-50-4 2-thiazolylamine 
• 1113-59-3 bromopyruvic acid 
• 64951-04-8 6-ethoxycarbonyl-imidazo<2,1-b>thiazole 

Downstream Products

• 1403332-82-0 (S)-N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)imidazo[2,1-b]thiazole-6-carboxamide 

Relevant academic research and scientific papers

Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles

[Chemical equation presented] The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor, multistep continuous flow process without isolation of intermediates.

DNA binding ligands targeting drug-resistant bacteria: Structure, activity, and pharmacology

We describe the lead optimization and structure-activity relationship of DNA minor-groove binding ligands, a novel class of antibacterial molecules. These compounds have been shown to target A/T-rich sites within the bacterial genome and, as a result, inhibit DNA replication and RNA transcription. The optimization was focused on N-terminal aromatic heterocycles and C-terminal amines and resulted in compounds with improved in vivo tolerability and excellent in vitro antibacterial potency (MIC ≥ 0.031 μg/mL) against a broad range of Gram-positive pathogens, including drug-resistant strains such as methicillin-resistant Stapylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), and vancomycin-resistant Enterococcus faecalis (VRE). In a first proof-of-concept study, a selected compound (35) showed in vivo efficacy in a mouse peritonitis model against methicillin-sensitive S. aureus infection with an ED50 value of 30 mg/kg.