53573-21-0

Upstream product

• 6271-51-8 2,3-dibromo-1-(4-bromo-phenyl)-3-phenyl-propan-1-one 
• 20822-01-9 3-(4-bromophenyl)-5-phenyl-4,5-dihydro-isoxazole 
• 112853-66-4 (4S,5R)-3-(4-Bromo-phenyl)-4-nitro-5-phenyl-4,5-dihydro-isoxazole 
• 67-56-1 methanol 
• 25856-01-3 1-(4-bromophenyl)-3-phenylpropane-1,3-dione 
• 7732-18-5 water 
• 536-74-3 phenylacetylene 
• 29203-58-5 4-bromo-N-hydroxybenzenecarboximidoyl chloride 
• 1774-66-9 3-(4-bromophenyl)-1-phenylprop-2-en-1-one 
• 14525-88-3 1-(4-bromophenyl)-2-phenylcyclopropane 
• 1122-91-4 4-bromo-benzaldehyde 
• 21067-52-7 4'-Brom-chalkonoxim 
• 112853-66-4 (4S,5S)-3-(4-Bromo-phenyl)-4-nitro-5-phenyl-4,5-dihydro-isoxazole 
• 14525-88-3 trans-1-(p-bromophenyl)-2-phenylcyclopropane 

Downstream Products

• 80223-05-8 3-(4-Bromo-phenyl)-2-methyl-5-phenyl-isoxazol-2-ium; iodide 
• 1133827-60-7 5-phenyl-3-[4-(phenylethynyl)phenyl]isoxazole 

Relevant academic research and scientific papers

TEMPO-Mediated Selective Synthesis of Isoxazolines, 5-Hydroxy-2-isoxazolines, and Isoxazoles via Aliphatic δ-C(sp3)-H Bond Oxidation of Oximes

Selective synthesis of three different bioactive heterocycles; isoxazolines, 5-hydroxy-2-isoxazolines and isoxazoles from the same starting material using TEMPO (2,2,6,6-Tetramethylpiperidin-1-oxyl) as a radical initiator is reported. Selectivity was achi

A Copper-Catalyzed Synthesis of Pyrroles through Photochemically Generated Acylazirines

A synthesis of highly substituted 2,4-diacylpyrroles through a Cu-catalyzed dimerization of acylazirines generated in situ by a photochemical valence isomerization is described. The shown methodology allows the use of simple precursors and a readily avail

Nitrosylsulfuric acid as a tandem reagent in the synthesis of 3,5-diarylisoxazoles from 1,2-diarylcyclopropanes

It was demonstrated that nitrosylsulfuric acid can be successfully used as a tandem nitrosating and oxidizing agent in the synthesis of 3,5-diarylisoxazoles from 1,2-diarylcyclopropanes. The reaction proceeds highly regioselectively in the case of symmetr

Trichloroisocyanuric acid mediated one-pot synthesis of 3,5-diarylisoxazoles from α,β-unsaturated ketones

A facile one-pot synthesis of 3,5-diarylisoxazoles from α,β-unsaturated ketones and hydroxylamine hydrochloride is reported. The reaction is efficiently promoted by trichloroisocyanuric acid (TCCA) to afford the desired products, mostly in high yields and

A convenient one-pot synthesis of 3,5-diarylisoxazoles via oxidative cyclisation using catalytic CuBr2 and oxone

A facile one-pot synthesis of 3,5-diarylisoxazoles from α,β-unsaturated ketones and hydroxylamine hydrochloride is reported. The reaction is efficiently promoted by catalytic CuBr2 and Oxone to afford the desired products mostly in high yields

TBAI-catalyzed intramolecular annulation of chalcone oximes toward isoxazoles

A TBAI-catalyzed intramolecular annulation of chalcone oximes toward isoxazoles was developed, providing 3,5-diarylisoxazoles in good yields. Functional groups such as methoxy, ethyoxyl, chloro, bromo, fluoro and nitro were well tolerated in this reaction

Copper-catalyzed aerobic oxidative C-O bond formation for the synthesis of 3,5-disubstituted isoxazoles from enone oximes

A direct access to 3,5-disubstituted isoxazoles has been accomplished through an intramolecular oxidative coupling reaction of enone oximes using a catalytic quantity of Cu(OAc)2. This method features an inexpensive metal catalyst, molecular ox

O-iodoxy benzoic acid–mediated synthesis of 3,5-diarylisoxazoles and isoxazole-3-carboxylic acids

A new, convenient, ecofriendly synthesis of 3,5-diarylisoxazoles is reported from a,b-unsaturated ketoximes. Similarly, a novel synthesis of isoxazole carboxylic acids is also reported. Both the methods use efficient, environmentally friendly, and nontoxic iodoxybenzoic acid (IBX) as an oxidative cyclizing reagent. Easy procedure, environmentally benign reaction conditions, and nontoxicity are advantages to the methodology.

1,3-Dipolar cycloaddition reaction applied to synthesis of new unsymmetric liquid crystal compounds-based isoxazole

In this study, a regioselective, simple and versatile copper(I)-catalyzed procedure for preparation of a series of liquid crystals based on unsymmetrical 3,5-disubstituted isoxazole was developed. Using different substituted chloro oximes and phenyl acety

Efficient and regioselective one-pot synthesis of 3-substituted and 3,5-disubstituted isoxazoles

(Figure Presented) A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with α,β-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.