6271-51-8

Usage

Uses

Used in Pharmaceutical Research:
2,3-dibromo-1-(4-bromophenyl)-3-phenylpropan-1-one is utilized as a key intermediate in the development of new pharmaceuticals due to its antimicrobial and anticancer properties. Its ability to target and inhibit the growth of various pathogens and cancer cells makes it a promising candidate for drug discovery and medicinal chemistry.
Used in Organic Synthesis:
In the field of organic synthesis, 2,3-dibromo-1-(4-bromophenyl)-3-phenylpropan-1-one serves as a versatile building block for the creation of more complex organic molecules. Its unique structure allows for various chemical reactions, facilitating the synthesis of a wide range of compounds with potential applications in different industries.
Used in Biotechnology:
2,3-dibromo-1-(4-bromophenyl)-3-phenylpropan-1-one is also employed in biotechnology for its potential applications in the development of novel bioactive compounds. Its antimicrobial and anticancer properties can be harnessed to engineer new bioproducts with therapeutic or industrial uses.
Used in Drug Development:
2,3-dibromo-1-(4-bromophenyl)-3-phenylpropan-1-one is explored for its potential in drug development, particularly for the treatment of infectious diseases and cancer. Its potent antimicrobial and anticancer activities, along with its structural diversity, make it an attractive candidate for the design and synthesis of new therapeutic agents.

Upstream product

• 2403-27-2 1-(4-bromophenyl)-3-phenyl-2-propen-1-one 
• 72758-69-1 (E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one 
• 64-19-7 acetic acid 
• 56-23-5 tetrachloromethane 

Downstream Products

• 53573-21-0 3-(4-bromophenyl)-5-phenylisoxazole 
• 7464-89-3 1,3,6,8-tetramethyl-1H,3H,6H,8H-pyrimido[4,5-g]pteridine-2,4,7,9-tetraone 
• 117836-59-6 2-(4-Bromo-phenyl)-1-phenyl-1,1a-dihydro-3,7b-diaza-cyclopropa[a]naphthalene-5-carbonitrile 
• 117836-46-1 2-(4-Bromo-phenyl)-1-phenyl-1,1a-dihydro-3,7b-diaza-cyclopropa[a]naphthalene 
• 127019-13-0 4-(4-Bromo-phenyl)-6-phenyl-1,3-diaza-bicyclo[3.1.0]hex-3-ene 
• 911678-04-1 1-(4-(4-bromophenyl)-6-phenylpyrimidin-2-yl)hydrazine-1-carbonitrile 
• 117836-65-4 2-Benzyl-6-bromo-3-(4-bromo-phenyl)-quinoxaline 
• 117836-63-2 2-benzyl-3-(4-bromo-phenyl)-quinoxaline 
• 93944-86-6 2-bromo-1-(4-bromophenyl)-3-phenyl-1,3-propanedione 
• 117836-52-9 5-Bromo-2-(4-bromo-phenyl)-1-phenyl-1,1a-dihydro-3,7b-diaza-cyclopropa[a]naphthalene 

Relevant academic research and scientific papers

A one-pot and three-component synthetic approach for the preparation of asymmetric and multi-substituted 1,4-dihydropyrazines

An efficient, one-pot and three-component synthesis of a new series of 2-acyl-3,4,6-triaryl-1,4-dihydropyrazines is described. This two-step strategy involves treatment of phenacyl bromides and anilines to give the nucleophilic substitution intermediate f

A new synthetic strategy towards 2,4,5-trisubstituted 1H-imidazoles and highly substituted pyrrolo[1,2-c]imidazoles by use of α-azidochalcones via Michael addition-cyclization followed by Wittig reaction

Efficient and facile protocols for the preparation of highly functionalized 1H-imidazoles and 5H-pyrrolo[1,2-c]imidazoles are described. Heating a mixture of an α-azidochalcones and N,N,N′,N′-tetramethyl guanidine under neat conditions gave the corresponding 2,4,5-trisubstituted 1H-imidazole via Michael addition-cyclization in excellent yields. Subsequently, the prepared 1H-imidazoles undergo addition-Wittig reaction with acetylenic esters in presence of triphenylphosphine in dichloromethane to afford 5H-pyrrolo[1,2-c]imidazoles in high yields.

I2O5-mediated bromohydroxylation and dibromination of olefins using KBr in water

An efficient and green bromohydroxylation and dibromination of various olefins mediated by I2O5 has been developed in this work. A series of olefins gave the corresponding α-bromo-alcohols and dibromides as the major products using KBr as the brominating reagent in aqueous medium at room temperature. The diastereo- and regio-selectivities are extremely high.

Ecofriendly bromination of chalcones and synthesis of flavones using grinding technique

Selective bromination of chalcones and 2'-hydroxychalcones has been carried out with ammonium bromide and ammonium persulphate using grinding technique at RT under aqueous moist condition to give α,β-dibromochalcones and α,β-dibromo-2'- hydroxychalcones respectively. α,β- Dibromo-2'-hydroxychalcones have been cyclodehydrobrominated with barium hydroxide moist and ethanol at RT to give flavones using grinding technique.

Process for preparing vinyl substituted beta-diketones

A process for preparing vinyl substituted beta-diketones includes reacting a halogen-containing beta-diketone with an olefin in a reaction zone under Heck coupling reaction conditions in the presence of a catalyst, a base, and an organic phosphine to provide a vinyl substituted beta-diketone product.

Imidazo[2,1-b]thiazole derivatives XII. Synthesis and immunoactivity in vitro on human T lymphocyte of several 3-aroylmethyl and 2-aroyl-3-methyl(aryl)-5,6-dihydroimidazo[2,1-b]thiazoles

To estimate the influence of aryl group position on the immunostimulant properties of imidazo[2,1-b]thiazole derivatives, several compounds were obtained and tested, versus tetramisole hydrochloride, on the mobilisation of CD2 receptor by human T lymphocyte. The synthesis use the action of monobrominated β-diketones on the 2-mercaptoimidazoline. So, 1-aryl-4-bromobutane-1,3-diones lead to 3-aroylmethyl-5,6-dihydroimidazo[2,1-b]thiazoles 4. Same, 1-aryl-2-bromobutane-1,3-diones and 1,3-diaryl-2-bromopentane-1,3-diones give respectively 3-aroyl-2-methyl-5,6-dihydroimidazo[2,1-b]thiazoles 5 and 3-aroyl-2-aryl-5,6-dihydroimidazo[2,1-b]thiazoles 6. Better yields are obtained when the reaction presents two steps. The first one, realized in acetone at room temperature, leads to an intermediate S-substituted 4,5-dihydroimidazole which, in second step, is cyclized in imidazo[2,1-b]thiazole compound via an unisolated carbinolamine. This one explains the univocal formation of 5 derivatives and the feasible blending in case of 6. The immunoactivity of several imidazothiazoles 4, 5 and 6 is lower that them of 6-aryl substituted compounds and particularly that the levamisole which is the reference product in this series.