5359-54-6Relevant academic research and scientific papers
Photoredox Catalytic Phosphite-Mediated Deoxygenation of α-Diketones Enables Wolff Rearrangement and Staudinger Synthesis of β-Lactams
Jiang, Zhiyong,Li, Haijun,Wei, Guo,Yang, Hui
supporting information, p. 19696 - 19700 (2021/08/03)
A novel visible-light-driven catalytic activation of C=O bonds by exploiting the photoredox chemistry of 1,3,2-dioxaphospholes, readily accessible from α-diketones and trialkyl phosphites, is reported. This mild and environmentally friendly strategy provides an unprecedented and efficient access to the Wolff rearrangement reaction which traditionally entails α-diazoketones as precursors. The resulting ketenes could be precisely trapped by alcohols/thiols to give α-aryl (thio)acetates and by imines to afford the valuable β-lactams in up to 99 % yields.
Catalytic C-C coupling of diazo compounds with arylboronic acids: Using surface modified sewage sludge as catalyst
Huang, Fei,Huang, He,Hughes, Timothy,Xie, Yuxing,Xu, Jun,Yu, Yang,Zhang, Zhipeng
, p. 4165 - 4173 (2020/07/14)
A green, mild and efficient synthesis of diarylmethines using sewage sludge-derived carbonaceous materials (SW) by perchloric acid catalyzed coupling reactions between diazo compounds and arylboronic acids was developed. The reaction shows a high level of functional tolerance and a broad substrate scope. Furthermore, the highly selective 1,2-alkyl shift products were furnished through the sterically demanding R4, R5 migration of diazo compounds (3-diazochromanone). The structures of 1,2-shift products have been further confirmed by single-crystal X-ray analysis. Significantly, the synthesis of the core structures of darifenacin (a clinical drug for overactive bladder syndrome, OAB) and diclofensine (a stimulant drug showing antidepressant and monoamine reuptake inhibitor activity) further demonstrated the efficacy and synthetic potential of this method. This journal is
Method for synthesizing aryl acetate derivative under catalysis of surface modified sludge charcoal
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Paragraph 0066-0068, (2019/11/12)
The invention discloses a method for synthesizing an aryl acetate derivative under the catalysis of surface modified sludge charcoal. According to the method, the construction of a C-C bond is realized by an arylation reaction realized by taking the surfa
Rh(I)-catalyzed cross-coupling of α-diazoesters with arylsiloxanes
Xia, Ying,Liu, Zhen,Feng, Sheng,Ye, Fei,Zhang, Yan,Wang, Jianbo
supporting information, p. 956 - 959 (2015/03/30)
An Rh(I)-catalyzed cross-coupling of diazoesters with arylsiloxanes has been successfully achieved. This transformation is a new method for the construction of the C(sp3)-C(sp2) bond, thus providing an alternative synthesis of α-aryl esters. Rh(I)-carbene migratory insertion has been proposed to be involved in this coupling reaction. The reaction represents the first example of utilizing arylsiloxane as the coupling partner in the carbene-involved cross-coupling reactions.
Synthesis of chiral α-diarylacetic esters by stereospecific 1,2-aryl migration promoted by in situ generated acetals from benzoins
Kothapalli, Raveendra Babu,Niddana, Ramana,Balamurugan, Rengarajan
supporting information, p. 1278 - 1281 (2014/04/03)
A simple protocol for the synthesis of α-diarylacetic esters from benzoins is described. In situ generated acetal assists rapid 1,2-aryl migration in a stereospecific manner, paving the way to make enantioenriched α-diarylacetic esters from easily accessi
PHOTOOXYDATION AND PHOTOOXYGENATION OF α-DIAZOKETONE IN ALCOHOL
Tomioka, Hideo,Kondo, Shingo,Misaki, Kiyotsugu,Izawa, Yasuji
, p. 2191 - 2194 (2007/10/02)
The investigation of the mechanism of oxydative-cleavage reaction of azibenzil in alcohol to give benzoates revealed the role of oxygen (either 1O2 or 3O2) in the photolysis of α-diazoketone-
