71292-81-4

Basic information

• Product Name: Ethanone, 2-(4-chlorophenyl)-2-hydroxy-1-phenyl-
• CAS NO: 71292-81-4
• Molecular Formula: C14H11ClO2
• Molecular Weight: 246.693
• Mol File: 71292-81-4.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(4-chlorophenyl)-2-hydroxy-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(4-chlorophenyl)-2-hydroxy-1-phenyl-(71292-81-4)
• EPA Substance Registry System: Ethanone, 2-(4-chlorophenyl)-2-hydroxy-1-phenyl-(71292-81-4)

Safety Data

• Hazardous Substances Data: 71292-81-4(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 43024-03-9 2-bromo-2-(4-chlorophenyl)-1-phenylethanone 
• 141-52-6 sodium ethanolate 
• 1074-12-0 phenylglyoxal hydrate 
• 108-90-7 chlorobenzene 
• 22711-23-5 4-chlorobenzil 
• 71292-76-7 diethyl α-trimethylsilyloxy-α-(4-chlorobenzoyl)benzylphosphonate 
• 613-90-1 benzoyl cyanide 
• 104-88-1 4-chlorobenzaldehyde 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 134-85-0 4-chlorobenzophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 1333394-45-8 (4-chlorophenyl)(2-phenyl-1,3-dithian-2-yl)methanol 

Downstream Products

• 13342-73-9 5-(4-chloro-phenyl)-4-phenyl-3H-oxazol-2-one 
• 22711-23-5 4-chlorobenzil 
• 1213264-77-7 (6R,7S,8S)-2-(4-chlorophenyl)-3-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6,7,8-triol 
• 1213264-69-7 (5S,6R,7S,8S)-2-(4-chlorophenyl)-5-hydroxymethyl-3-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6,7,8-triol 
• 1333394-62-9 (S)-1-(4-chlorophenyl)-2-oxo-2-phenylethyl butyrate 
• 23187-09-9 4⁽⁵⁾-(4-chlorophenyl)-2,3-dihydro-5⁽⁴⁾-phenyl-1H-imidazole-2-thione 
• 22394-04-3 2-(4-chloro-phenyl)-3,4,5-triphenyl-pyrrole 
• 5359-54-6 ethyl 2-(4-chlorophenyl)-2-phenylacetate 
• 39774-18-0 p-chlorobenzoin 
• 5038-56-2 α'-Acetoxy-α,4-dichlor-stilben 
• 100-52-7 benzaldehyde 
• 74-11-3 para-chlorobenzoic acid 
• 5088-11-9 2-chloro-2-(4-chlorophenyl)-1-phenylethanone 

Relevant articles and documents

Visible Light Enabled Formal Cross Silyl Benzoin Reaction as an Access to α-Hydroxyketones

In this work, a visible-light enabled coupling of acylsilanes with aldehydes to give a range of cross-benzoin type products α-hydroxyketones is described. The reaction could proceed at ambient temperature, with the irradiation of low energy visible light, and without addition of photosensitizer or any other additives. (Figure presented.).

Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors

A series of 4,5-diaryl-1H-imidazole-2(3H)-thione was synthesized and their inhibitory potency against soybean 15-lipoxygenase and free radical scavenging activities were determined. Compound 11 showed the best IC50 for 15-LOX inhibition (IC50 = 4.7 μM) and free radical scavenging activity (IC50 = 14 μM). Methylation of SH at C2 position of imidazole has dramatically decreased the 15-LOX inhibition and radical scavenging activity as it can be observed in the inactive compound 14 (IC50 >250 μM). Structure activity similarity (SAS) showed that the most important chemical modification in this series was methylation of SH group and Docking studies revealed a proper orientation for SH group towards Fe core of the 15-LOX active site. Therefore it was concluded that iron chelating could be a possible mechanism for enzyme inhibition in this series of compounds.

Mechanism and scope of the cyanide-catalyzed cross silyl benzoin reaction

In this work, cross silyl benzoin addition reactions between acylsilanes (1) and aldehydes (2) catalyzed by metal cyanides are described. Unsymmetrical aryl-, heteroaryl-, and alkyl-substituted benzoin adducts can be generated in moderate to excellent yie