535925-40-7

Usage

Uses

Used in Coordination Chemistry:
(DTBM)2P(O)H is used as a ligand for [forming coordination complexes] with [various metal ions], which is important for [studying metal ion interactions and properties].
Used in Catalysis:
(DTBM)2P(O)H is used as a ligand in [catalytic reactions] for [improving reaction efficiency and selectivity] due to its ability to form stable complexes with metal ions.
Used in Synthesis of Phosphorus Compounds:
(DTBM)2P(O)H is used as a starting material or reagent in the [synthesis of various organic and inorganic phosphorus compounds] for [creating new molecules with potential applications in different industries].
Used in Pharmaceutical Industry:
(DTBM)2P(O)H could potentially be used as a [pharmaceutical intermediate] for [developing new drugs], given its ability to form complexes with metal ions, which may have therapeutic applications.
Used in Material Science:
(DTBM)2P(O)H might be utilized in the [development of new materials], such as [coordination polymers or metal-organic frameworks (MOFs)], due to its coordination chemistry properties.

Upstream product

• 1139-52-2 4-bromo-2,6-di-tert-butylphenol 
• 1516-96-7 4-bromo-2,6-di-tert-butylanisole 
• 96-36-6 methyl phosphite 
• 762-04-9 Diethyl phosphonate 

Downstream Products

• 535925-36-1 bis(3,5-di-tert-butyl-4-methoxyphenyl)-(2-bromophenyl)phosphine oxide 
• 1173023-24-9 bis(3,5-di-tert-butyl-4-methoxyphenyl)chlorophosphine 
• 1312606-31-7 C₄₉H₆₇O₄P 
• 1312606-28-2 C₃₆H₅₁O₃P 
• 1312606-25-9 C₃₆H₅₁O₄P 
• 1312606-23-7 C₄₁H₅₉O₅P 
• 1198616-95-3 C₄₃H₅₄F₃O₆PS 
• 1026682-39-2 [1,1'-biphenyl]-2,2'-diylbis(bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphine oxide) 
• 212713-08-1 chlorobis(4-methoxy-3,5-di(tert-butyl)phenyl)phosphine 

Relevant academic research and scientific papers

Mechanistically Guided Design of Ligands That Significantly Improve the Efficiency of CuH-Catalyzed Hydroamination Reactions

Using a mechanically guided ligand design approach, a new ligand (SEGFAST) for the CuH-catalyzed hydroamination reaction of unactivated terminal olefins has been developed, providing a 62-fold rate increase over reactions compared to DTBM-SEGPHOS, the previous optimal ligand. Combining the respective strengths of computational chemistry and experimental kinetic measurements, we were able to quickly identify potential modifications that lead to more effective ligands, thus avoiding synthesizing and testing a large library of ligands. By optimizing the combination of attractive, noncovalent ligand-substrate interactions and the stability of the catalyst under the reaction conditions, we were able to identify a finely tuned hybrid ligand that greatly enables accelerated hydrocupration rates with unactivated alkenes. Moreover, a modular and robust synthetic sequence was devised, which allowed for the practical, gram-scale synthesis of these novel hybrid ligand structures.

Enantioselective Rhodium-Catalyzed Atom-Economical Macrolactonization

A highly attractive route toward macrolactones, which form the cyclic scaffold of a multitude of diverse natural compounds, is described. Although many chemical approaches to this structural motif have been explored, an asymmetric variant of the cyclization is unprecedented. Herein we present an enantioselective macrolactonization through an intramolecular atom-economical rhodium-catalyzed coupling of ω-allenyl-substituted carboxylic acids. The use of a modified diop ligand, chiral DTBM-diop, led to high enantioselectivity (up to 93 % ee). The reaction tolerated a large variety of functionalities, including α,β-unsaturated carboxylic acids and depsipeptides, and provided the desired macrocycles with very high enantio- and diastereoselectivity.

Process research on the asymmetric hydrogenation of a benzophenone for developing the manufacturing process of the squalene synthase inhibitor TAK-475

A practical synthetic method for the synthesis of the chiral benzhydrol 8, which is the key intermediate of the squalene synthase inhibitor TAK-475 (1), has been developed. The method, via asymmetric hydrogenation of the benzophenone 7, employed Noyori's ruthenium precatalyst of the type [RuCl 2(diphosphine)(diamine). We focused on tuning of the chiral diphosphine, and have discovered a novel ligand, DADMP-BINAP (18c), for the catalyst that has allowed reduction of the operating pressure in the asymmetric hydrogenation. The precatalyst containing 18c performed effectively at low hydrogen pressure (1 MPa) with sufficient enantioselectivity, and the result enabled us to successfully obtain enantiomerically pure 8 on a multikilogram scale.

TRANSITION METAL COMPLEX HAVING DIPHOSPHINE COMPLEX AS LIGAND

A transition metal complex having 2,2'-bis[bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-1,1'-binaphthyl as a ligand. The presence of the transition metal complex in the reaction system of an asymmetric reaction system allows the preparation of an objective compound having an objective absolute configuration with improved efficiency.

PROCESS FOR PREPARATION OF DIPHOSPHINE COMPOUNDS AND INTERMEDIATES FOR THE PROCESS

A production method of a_compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.