53606-33-0Relevant academic research and scientific papers
Three-Dimensional Heterocycles by Iron-Catalyzed Ring-Closing Sulfoxide Imidation
Yu, Hao,Li, Zhen,Bolm, Carsten
supporting information, p. 12053 - 12056 (2018/09/11)
A general and atom-economical method for the synthesis of cyclic sulfoximines by intramolecular imidations of azido-containing sulfoxides using a commercially available FeII phthalocyanine (FeIIPc) as catalyst has been developed. The method conveys a broad functional group tolerance and the resulting three-dimensional heterocycles can be modified by cross-coupling reactions.
Iron-Promoted Tandem Cyclization of 1,3-Diynyl Chalcogen Derivatives with Diorganyl Dichalcogenides for the Synthesis of Benzo[b]furan-Fused Selenophenes
Neto, José S. S.,Iglesias, Bernardo A.,Back, Davi F.,Zeni, Gilson
supporting information, p. 3572 - 3585 (2016/11/25)
A double intramolecular 5-endo-dig cyclization of butyl[2-(phenylbuta-1,3-diynyl)phenyl]chalcogens has been employed in a selective preparation of benzo[b]chalcogenopheno[2,3-d]furans. Several reaction parameters were studied to determine the best reaction conditions and we observed that the reaction of butyl[2-(phenylbuta-1,3-diynyl)phenyl]chalcogens (0.25 mmol) with iron(III) chloride hexahydrate (2.0 equiv.) and diorganyl diselenides (1.75 equiv.) at reflux of dichloromethane was the most appropriate to give the products in 35–89% yields. These standard reaction conditions were compatible with many functional groups in the substrates, such as methyl, chlorine, fluorine, methoxy and heteroaryl. This protocol was also efficient for diorganyl diselenides but it was ineffective with diorganyl disulfides and ditellurides. In a competition among selenium, sulfur and oxygen nucleophiles we observed that the nucleophilicity and steric effects of the competing functional groups were determinant factors for the selectivity of the cyclization. The benzo[b]chalcogenopheno[2,3-d]furans had absorptions in the UV region (300–350 nm range) with molar absorptivity coefficient values ascribed to spin and symmetry allowed π–π* electronic transitions. An emission located in the purple region (380–440 nm range), with a Stokes shift of between 65–100 nm, is probably associated to the charge transfer character of the excited state. (Figure presented.).
SULFUR CHELATED RUTHENIUM COMPOUNDS USEFUL AS OLEFIN METATHESIS CATALYSTS
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Paragraph 0062, (2014/06/23)
Sulfur chelated ruthenium compounds represented by the following formula: wherein M indicates the ruthenium metal bound to a benzylidene carbon; R represents C1-C7 alkyl group or optionally substituted aryl; X1 and X2 each independently represent halogen; Y1 and Y2 each independently denote unsubstituted or alkyl-substituted phenyl; and Z independently represents hydrogen, electron withdrawing or electron donating substituent, with m being an integer from 1 to 4, and processes and compositions related thereto.
Synthesis and fungicidal activities of novel benzothiophene-substituted oxime ether strobilurins
Tu, Song,Xie, Ya-Qiang,Gui, Si-Zhe,Ye, Li-Yi,Huang, Zi-Long,Huang, Yi-Bing,Che, Li-Ming
supporting information, p. 2173 - 2176 (2014/05/06)
Twenty-one novel benzothiophene-substituted oxime ether strobilurins, which employed a benzothiophene group to stabilise the E-styryl group in Enoxastrobin (an unsaturated oxime strobilurin fungicide developed by Shenyang Research Institute of Chemical Industry, China) were designed and synthesised. The biological assay indicated that most compounds exhibited good or excellent fungicidal activities, especially against Colletotrichum lagenarium and Puccinia sorghi Schw. In addition, methyl 3-methoxypropenoate oxime ethers and N-methoxy-carbamic acid methyl esters exhibited good in vivo fungicidal activities against Erysiphe graminis, Colletotrichum lagenarium and Puccinia sorghi Schw. under the tested concentrations. Notably, (E,E)-methyl 3-methoxy-2-(2-((((6-chloro-1-(1H-benzo[b]thien-2-yl)ethylidene)amino)oxy) methyl)phenyl)propenoate (5E) exhibited more potent in vivo fungicidal activities against nearly all of the tested fungi at a concentration of 0.39 mg/L compared to Enoxastrobin.
New CRTH2 Antagonists
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Page/Page column 38, (2012/12/13)
The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
Synthesis and evaluation of 1-(benzo[b]thiophen-2-yl)ethanone analogues as novel anti-osteoporosis agents acting on BMP-2 promotor
Liu, Zong-ying,He, Xiao-bo,Yang, Zhao-yong,Shao, Hua-yi,Li, Xue,Guo, Hui-fang,Zhang, Yue-qin,Si, Shu-yi,Li, Zhuo-rong
scheme or table, p. 4167 - 4170 (2010/04/26)
A novel series of 1-(benzo[b]thiophen-2-yl)ethanone analogues were prepared and evaluated for enhancing BMP-2 expression. Compounds 1-5, 7, 8, 12, 13 and 16, with upregulation rate values of 35.6%, 27.9%, 39.8%, 32.0%, 37.1%, 30.2%, 28.0%, 33.5%, 22.8% an
Sulfur chelated ruthenium compounds useful as olefin metathesis catalysts
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, (2009/07/03)
Sulfur chelated ruthenium compounds and methods and compositions involving the same. A method may relate to subjecting an olefin to a metathesis reaction in the presence of a sulfur chelated ruthenium compound. A composition may relate to an olefin starting material dissolved in an organic solvent together with a sulfur chelated ruthenium compound.
Latent sulfur chelated ruthenium catalysts: Steric acceleration effects on olefin metathesis
Kost, Tamar,Sigalov, Mark,Goldberg, Israel,Ben-Asuly, Amos,Lemcoff, N. Gabriel
, p. 2200 - 2203 (2008/09/21)
A series of sulfur chelated dormant ruthenium olefin metathesis catalysts is presented. The catalysts prepared were shown to possess the uncommon cis-dichloro arrangement and were mostly inactive at room temperature. By systematically modifying the size of the substituent groups at the chelating sulfur atom, catalyst activity at different temperatures was significantly affected; more bulky substituents fomented activity at lower temperatures. The catalysts were also shown to be stable in solution and retained their catalytic activity even after being exposed to air for two weeks.
Novel thiolated amino-alcohols as chiral ligands for copper-catalyzed asymmetric nitro-aldol reactions
Mansawat, Woraluk,Saengswang, Ittiphol,U-prasitwong, Palita,Bhanthumnavin, Worawan,Vilaivan, Tirayut
, p. 4235 - 4238 (2008/02/08)
Thiolated amino-alcohols have been synthesized and evaluated as a potential new class of chiral ligands for copper-catalyzed nitro-aldol reactions. The model nitro-aldol reaction took place smoothly at ambient temperature in the presence of catalytic amounts (5-15 mol %) of the ligands and copper(II) acetate to afford the nitro-aldol product in good to excellent yield without accompanying dehydration. Amino-alcohol ligands bearing N-(2-alkylthio)benzyl substituents provided only modest enantioselectivities (22-46% ee) while those carrying N-2-thienylmethyl substituents provided better enantioselectivities (up to 75% ee). A range of aromatic aldehydes were acceptable for the nitro-aldol reaction with nitromethane, giving moderate to good enantioselectivities (69-88% ee).
Synthesis, characterization, and X-ray structural analysis of some half-sandwich ruthenium(II) arene complexes with new N,S-donor Schiff base ligands
Halbach, Dominic P.,Hamaker, Christopher G.
, p. 3349 - 3361 (2007/10/03)
A series of cationic, half-sandwich ruthenium complexes with the general formula [(η6-arene)RuCl(R1S-C6H4-2-CH{double bond, long}NR2)]+ (arene = p-cymene or hexamethylbenzene; R1
