53608-37-0Relevant academic research and scientific papers
Synthesis method of polysubstituted pyrazole compound
-
Paragraph 0025; 0091-0093, (2018/09/08)
The invention discloses a synthesis method of a polysubstituted pyrazole compound. Compounds shown as formulas in the description are used as reaction raw materials and react under the action of a Lewis base to generate a compound shown as the formula in
Regioselective [3 + 2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles
Liu, Kun,Shang, Xinye,Cheng, Yuyu,Chang, Xiaoyong,Li, Pengfei,Li, Wenjun
supporting information, p. 7811 - 7814 (2018/11/21)
A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and 1,3-dicarbonyl compounds has been developed. In the presence of DMAP combined with Et3N, hydrazonyl chlorides reacted with N-phenyl-3-oxobutanamides smoothly to afford
Conversion des Cis- et Trans-Pyrazolines en Pyrazoles Sur Support Mineral Impregne de Nitrate Ferrique ou Cuivrique
Bougrin, Khalid,Soufiaoui, Mohamed,Yazidi, Mohamed El
, p. 4065 - 4068 (2007/10/02)
Pyrazoles are prepared from cis- and trans-pyrazolines with good yield in dichloromethane under mild reaction conditions using the inexpensive clay-supported iron (III) nitrate "Clayfen" or copper (II) nitrate "Claycop".
The Regioselectivity in the Formation of Pyrazolines and Pyrazoles from Nitrile Imines
Hassaneen, Hamdi M.,Hilal, Rifaat H.,Elwan, Nehal M.,Harhash, Abdelhamid,Shawali, Ahmad S.
, p. 1013 - 1016 (2007/10/02)
The 1,3-cycloaddition of the nitrile imines 2a-e to the carbon-carbon double bond in benzalacetophenone leads to the formation of 4-phenyl-5-benzoylpyrazolines 3a-e which were converted into 4-phenyl-5-benzoylpyrazoles 5a-e upon treatment with chloranil in xylene.However, the cycloaddition of 2a-e to the carbon-carbon double bond in the enol tautomer of dibenzoylmethane gives the regioisomers 5-phenyl-5-hydroxy-4-benzoylpyrazolines which loose elements of water to yield 4-benzoyl-5-phenylpyrazoles 6a-e.The orientation in these reactions are interpretted in terms of the Frontier Molecular Orbital theory.The structures of the products 3,5 and 6 were substantiated by their chemical reactions and alternate synthesis whereever possible.
Synthesis of 4-Acyl- and 4-Alkoxy-carbonylpyrazoles
Al-Saleh, Fowzia S.,Khawaja, Ibtisam K. Al,Joule, John A.
, p. 642 - 645 (2007/10/02)
N'-Aroyl- or N'-acetyl, N'-phenyl- or N'-methyl-hydrazino-derivatives (1) of 1,3-dicarbonyl compounds can be converted by mild base treatment into 5-aryl- or 5-methyl-, 1-phenyl- or 1-methylpyrazoles carrying an acyl or alkoxycarbonyl group at C-4.
