5361-20-6Relevant articles and documents
Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III
Guiles, Joseph,Sun, Xicheng,Critchley, Ian A.,Ochsner, Urs,Tregay, Ming,Stone, Kim,Bertino, Jennifer,Green, Louis,Sabin, Rob,Dean, Frank,Garry Dallmann,McHenry, Charles S.,Janjic, Nebojsa
scheme or table, p. 800 - 802 (2009/08/15)
High throughput screening led to the discovery of a novel series of quinazolin-2-ylamino-quinazolin-4-ols as a new class of DNA polymerase III inhibitors. The inhibition of chromosomal DNA replication results in bacterial cell death. The synthesis, struct