53627-76-2Relevant articles and documents
Pyrazolo[5,1-c][1,2,4]triazoles: Antimicrobial, Antitumor Activities, and Computational Docking Studies
Farghaly, Thoraya A.,Abdallah, Magda A.,Mahmoud, Huda K.,El-Metwaly, Nashwa,Elaasser, Mahmoud
, p. 2859 - 2866 (2017)
A new series of pyrazolotriazoles 7a–l, 11, and 15a–c derived from the reaction of 3-amino-4-(arylhydrazono)-4,5-dihydropyrazol-5-one 3a,b with various types of hydrazonoyl chlorides 4, 10, 12, and 13 was being synthesized in existence of triethylamine. The spectral data were assured the postulated structures for all compounds. All 7-arylazopyrazolo[5,1-c][1,2,4]triazole derivatives 7a–l, 11, and 15a–c have been evaluated for their antimicrobial and antitumor activities, and the results show that some derivatives have good to mild utility as antitumor and antibacterial operators. Moreover, the computational studies using AutoDock tools 4.2 are confirming the results in biological activity.
INVESTIGATION IN THE FIELD OF ARYLHYDRAZONES OF SUBSTITUTED GLYOXYLIC ACID. XXVII. N-ARYLCYANOMALONOTHIOAMIC BENZYLIDENEHYDRAZIDES IN THE JAPP-KLINGEMANN REACTION
Dubenko, R.G.,Gorbenko, E. F.,Pel'kis, P. S.
, p. 1536 - 1543 (2007/10/02)
The reaction of N'-benzylidenecyanoacetohydrazides with aryl isothiocyanates, leading to the formation of N-arylcyanomalonothioamic benzylidenehydrazides, was investigated.The N-arylcyanomalonothioamic benzylidenehydrazides react with arenediazonium salts
