53661-35-1Relevant academic research and scientific papers
Synthesis and some conversions of partially hydrogenated 1-aminopyrano(thiopyrano)[4,3-d]-pyrazolo[3,4-b]pyridines and pyrazolo[3,4-c]isoquinolines
Paronikyan,Sirakanyan,Noravyan
, p. 374 - 378 (2003)
We have synthesized derivatives of pyrano(thiopyrano)[4,3-d]pyrazolo[3,4-b]pyridine and pyrazolo-[3,4-c]isoquinoline, and we have also carried out some conversions with them.
Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase
Van Linden, Oscar P.J.,Farenc, Carine,Zoutman, Willem H.,Hameetman, Liesbeth,Wijtmans, Maikel,Leurs, Rob,Tensen, Cornelis P.,Siegal, Gregg,De Esch, Iwan J.P.
, p. 493 - 500 (2012/03/11)
The in silico identification, optimization and crystallographic characterization of a 6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-1-amine scaffold as an inhibitor for the EPHA4 receptor tyrosine kinase is described. A database containing commercially
EPHA4 RTK INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS AND CANCER
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Page/Page column 35, (2010/05/13)
The present invention is directed to compounds of generic formula (I) which are inhibitors of ephrin A4. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatm
