53661-29-3Relevant academic research and scientific papers
One-Pot Synthesis of 3-Oxocycloalka[c]pyridines
Geronikaki, A.,Hakobyan, E. K.,Hovakimyan, A. A.,Kartsev, V. G.,Sirakanyan, S. N.
, p. 1748 - 1752 (2021/12/13)
Abstract: A new efficient one-pot procedure has been developed for the synthesis of 1-substituted partially hydrogenated 3-oxocycloalka[c]pyridine-4-carbonitriles by reaction of cyclopentanone or cyclohexanone with morpholine, acyl chloride, and cyanoacetamide. The proposed procedure is advantageous due to shorter reaction time and smaller amounts of the solvents and reactants.
Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase
Van Linden, Oscar P.J.,Farenc, Carine,Zoutman, Willem H.,Hameetman, Liesbeth,Wijtmans, Maikel,Leurs, Rob,Tensen, Cornelis P.,Siegal, Gregg,De Esch, Iwan J.P.
supporting information; experimental part, p. 493 - 500 (2012/03/11)
The in silico identification, optimization and crystallographic characterization of a 6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-1-amine scaffold as an inhibitor for the EPHA4 receptor tyrosine kinase is described. A database containing commercially
Amide-Catalysed Isomerisation of 5,6-Dihydroisoquinolines: a Novel Synthesis of 1,2-Dihydroisoquinolines
Kasturi, Tirumalai Rangachar,Krishnan, Lalitha,Prasad, Ramanujam Srinivasa
, p. 63 - 68 (2007/10/02)
Knoevenagel condensation of 2-acylcyclohexanones or 2-ethoxycarbonylcyclohexanone with either cyanoacetamide or malononitrile followed by silver salt alkylation gave the 5,6,7,8-tetrahydroisoquinolines (3a-i).Chromic acid oxidation of the 5,6,7,8-tetrahyd
