53673-16-8

Upstream product

• 547-63-7 Methyl isobutyrate 
• 107-15-3 ethylenediamine 
• 97-62-1 Ethyl isobutyrate 
• 79-31-2 isobutyric Acid 

Downstream Products

• 56202-72-3 1-phenyl-2-(β-isobutyramidoethyl)amino-ethanol 
• 53671-22-0 N-{2-[3-(2-Chloro-phenoxy)-2-hydroxy-propylamino]-ethyl}-isobutyramide 
• 53671-26-4 N-{2-[3-(2,5-Dichloro-phenoxy)-2-hydroxy-propylamino]-ethyl}-isobutyramide 
• 58027-39-7 3-<(2-isobutyramidoethyl)amino>-1-(2-carbamoylphenoxy)propan-2-ol 
• 83029-57-6 N-(2-[2-hydroxy-3-phenoxypropyl]aminoethyl)-isobutyramide 
• 56203-08-8 2-(β-isobutyramidoethyl)-amino-1-p-methoxyphenylethanol 
• 58027-11-5 1-p-(3-n-butylureido)phenoxy-3-β-isobutyramidoethylamino-2-propanol 
• 56203-07-7 2-(β-isobutyramido-ethyl)amino-1-p-bromophenylethanol 
• 58027-69-3 N-(2-{3-[4-(Acetylamino-methyl)-phenoxy]-2-hydroxy-propylamino}-ethyl)-isobutyramide 
• 58027-66-0 N-{2-[3-(2-Chloro-4-propionylamino-phenoxy)-2-hydroxy-propylamino]-ethyl}-isobutyramide 
• 58027-94-4 N-{2-[2-Hydroxy-3-(2-methoxy-4-ureidomethyl-phenoxy)-propylamino]-ethyl}-isobutyramide 
• 58027-22-8 N-{2-[2-Hydroxy-3-(2-methylcarbamoylmethoxy-phenoxy)-propylamino]-ethyl}-isobutyramide 
• 58027-62-6 1-(2-nitro-4-propionamidophenoxy)-3-β-isobutyramidoethylamino-2-propanol 
• 58027-25-1 N-[2-(2-Hydroxy-3-{2-[(2-hydroxy-ethylcarbamoyl)-methoxy]-phenoxy}-propylamino)-ethyl]-isobutyramide 

Relevant academic research and scientific papers

Colloid and nanosized catalysts in organic synthesis: XIII. Synthesis of 2-R-2-imidazolines catalyzed by copper and iron oxide nanoparticles

The reaction of carboxylic acids with ethylenediamine catalyzed by copper or iron oxide nanoparticles proceeds at 80°C with azeotropic water distilling off during 2-8 h to form 2-R-2-imidazolines. Acyl and diacyl derivatives of ethylenediamine are formed in the reaction as side products.

Relationships between conformational behaviour and binding affinity towards β1 and β2 adrenoceptors of some chiral phenoxypropanolamines with bulky N-substituents

The optical isomers of a series of phenoxypropanolamine compounds with N-substituents bulkier than isopropyl have been synthesized, and their binding affinity towards β1 and β2-adrenoceptors has been determined. A computational study, including a Molecular Dynamics (MD) simulation and quenching in water and a GRID analysis provided some useful suggestions for possible interpretation patterns for the different affinity exhibited by the compounds studied.

New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same

A compound of the formula: STR1 wherein R1 is lower alkyl optionally substituted with a substituent selected from the group consisting of acyl, hydroxy, lower alkoxy, aryl, lower alkylthio and a group of the formula: STR2 in which R5 is hydrogen or acyl and R6 is hydrogen or lower alkyl; aryl; or amino optionally substituted with substituent(s) selected from the group consisting of lower alkyl and acyl; and R2 is hydrogen or lower alkyl; or R1 and R2 are taken together with the attached nitrogen atom to form a heterocyclic group optionally substituted with substituent(s) selected from the group consisting of lower alkyl, hydroxy(lower )alkyl, lower alkoxy(lower)alkyl, acyl(lower)alkyl, oxo and acyl; R3 is hydrogen or lower alkyl; and R4 is lower alkyl; and its pharmaceutically acceptable salt, processes for the preparation thereof and pharmaceutical composition comprising the same.