53677-98-8

Upstream product

• 98907-26-7 2-amino-3′,6′-dihydroxyspiro[isoindoline-1,9′-xanthen]-3-one 
• 596-09-8 fluorescein diacetate 
• 2321-07-5 fluorescein 

Downstream Products

• 53677-97-7 leuco-fluorescein 

Relevant academic research and scientific papers

An RGB color-tunable turn-on electrofluorochromic device and its potential for information encryption

RGB color-tunable "turn-on" electrofluorochromic (EFC) devices with high color purity (457 nm for blue, 539 nm for green, and 641 nm for red), relatively quick response/fading speeds and remarkable fluorescence contrast ratios are successfully fabricated. They exhibit great potential for increasingly important multistage encrypted information storage and displays.

A reaction based chromofluorogenic turn-on probe for specific detection of fluoride over sulfide/thiols

A new reaction based probe fluorescein nosylate (R1) has been designed and synthesized for selective recognition of F-in acetonitrile (CH3CN) by exploiting both its nucleophilic and basic character. Probe R1 consists of fluorescein dye as a signalling unit while 4-nitrobenzenesulfonyl chloride as the masking unit. The F-plays the role of de-masking agent to set free the fluorescein moiety in its open form from R1 leading to significant changes in its absorption/emission profile. The detection of F-amidst of sulfide/thiols through receptors undergoing nucleophilic scission is a tedious job due to similarity in their extent of basicity/nucleophilicity. Here, we present a convenient solution for the same in the form of R1 which detects F-selectively over sulfide/thiols in CH3CN with a high detection limit of 4.6 × 10-7M and 2.75 × 10-8M determined through UV-visible and fluorescence titration data, respectively.

Monitoring singlet oxygen and hydroxyl radical formation with fluorescent probes during photodynamic therapy

Singlet oxygen (1O2) is the primary oxidant generated in photodynamic therapy (PDT) protocols involving sensitizers resulting in type II reactions. 1O2 can give rise to additional reactive oxygen species (ROS) s

A highly selective dual channel hypochlorite probe based on fluorescein and 1,10-phenanthroline

In this study, a highly selective dual channel (UV-vis and fluorescence) responsive hypochlorite probe based on fluorescein and 1,10-phenanthroline is described. It is found that this compound can be used as both a fluorogenic and chromogenic probe for the detection of the hypochlorite ion in aqueous solution. NMR and mass spectral analysis show that the probe reacts with the hypochlorite ion, which triggers both a remarkable enhancement of the emission intensity (turn on), and a color change from a colorless state to yellow. More importantly, the probe displays extremely high selectivity to hypochlorite among other common ROS and many ions in aqueous solution.

A ratiometric fluorescent system for carboxylesterase detection with AIE dots as FRET donors

A ratiometric fluorescent system for CaE detection with AIE dots as the FRET donors was designed. Upon enzymatic reaction, electrostatic interaction between the cationic TPE-N+ dots and the enzymatic reaction product - the negatively charged fluorescein molecules - allows the FRET process to proceed, thus affording the ratiometric fluorescence CaE assay.