537039-66-0

Basic information

• Product Name: uridine 5'-diphospho-2-azido-2-deoxy-α-D-glucopyranoside
• CAS NO: 537039-66-0
• Molecular Weight: 591.319
• Mol File: 537039-66-0.mol

Chemical Properties

• CAS DataBase Reference: uridine 5'-diphospho-2-azido-2-deoxy-α-D-glucopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: uridine 5'-diphospho-2-azido-2-deoxy-α-D-glucopyranoside(537039-66-0)
• EPA Substance Registry System: uridine 5'-diphospho-2-azido-2-deoxy-α-D-glucopyranoside(537039-66-0)

Safety Data

• Hazardous Substances Data: 537039-66-0(Hazardous Substances Data)

Upstream product

• 63-39-8 UTP 
• 171032-74-9 1,3,4,6-tetra-O-acetyl-2-azido-2-deoxy-D-glucopyranose 

Downstream Products

• 1109-79-1 uridine 5'-(2-amino-2-deoxy-α-D-glucopyranosyl)-diphosphate 

Relevant articles and documents

Compositions and methods for the transfer of a hexosamine to a modified nucleotide in a nucleic acid

Nucleic acids comprising β-glucosaminyloxy-5-methylcytosine; compositions, kits and methods of producing the nucleic acids using a glycosyltransferase; and methods of using the nucleic acids are described.

CHEMOENZYMATIC SYNTHESIS OF HEPARIN AND HEPARAN SULFATE ANALOGS

The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.

Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP)

A promiscuous UDP-sugar pyrophosphorylase (BLUSP) was cloned from Bifidobacterium longum strain ATCC55813 and used efficiently with a Pasteurella multocida inorganic pyrophosphatase (PmPpA) with or without a monosaccharide 1-kinase for one-pot multienzyme synthesis of UDP-galactose, UDP-glucose, UDP-mannose, and their derivatives. Further chemical diversification of a UDP-mannose derivative resulted in the formation of UDP-N-acetylmannosamine. The Royal Society of Chemistry 2012.

One-pot three-enzyme synthesis of UDP-GlcNAc derivatives

A Pasteurella multocida N-acetylglucosamine 1-phosphate uridylyltransferase (PmGlmU) was cloned and used efficiently with an N-acetylhexosamine 1-kinase (NahK-ATCC55813) and an inorganic pyrophosphatase (PmPpA) for one-pot three-enzyme synthesis of UDP-GlcNAc derivatives with or without further chemical diversification.