53744-36-8

Upstream product

• 98-86-2 acetophenone 
• 642-31-9 9-anthracene aldehyde 
• 100622-34-2 anthracene-9-boronic acid 
• 93-55-0 1-phenyl-propan-1-one 
• 87337-01-7 cis-3-(9-anthryl)-1-phenyl-prop-2-en-1-one 

Downstream Products

• 97580-15-9 2-Phenyl-8H-1-oxa-dibenzo[e,h]azulene 
• 87337-01-7 cis-3-(9-anthryl)-1-phenyl-prop-2-en-1-one 
• 74387-96-5 3-(9-anthryl)-1-phenyl-1-propanone 
• 74387-95-4 1-(9-Anthryl)-3-(phenyl)propane 
• 21515-25-3 1,3-diphenyl-5-(9-anthryl)-2-pyrazoline 

Relevant academic research and scientific papers

Unraveling relation between nonlinear absorption and structure of push pull ornamented anthracenyl chalcone derivatives

Using green chemical method a series of fifteen systematically substituted 3-(9-substituted anthracen-10-yl)-1-(4-phenyl substituted)prop-2-en-1-one derivatives having high nonlinear absorption coefficient have been synthesized. The nonlinear absorption properties of these compounds were studied using nanosecond pulses at 532 nm wavelength. All 15 derivatives are found to show high nonlinear absorption in the range of 35–640 cm/GW. Among these the derivatives with –NO2 as one of the substitution group show higher nonlinear absorption. The origin of high nonlinear absorption with low linear absorption in the compounds has been attributed to two-step two-photon absorption process. We have shown that the energy bands of these compounds are distributed such that for excitation at 532 nm they have strong nonlinear absorption. These properties of the reported compounds make them a potential candidate for biological imaging and other applications which are based on nonlinear absorption.

Aryl-4,5-dihydro-1H-pyrazole-1-carboxamide derivatives bearing a sulfonamide moiety show single-digit nanomolar-to-subnanomolar inhibition constants against the tumor-associated human carbonic anhydrases IX and XII

A series of new 3-phenyl-5-aryl-N-(4-sulfamoylphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide derivatives was designed here, synthesized, and studied for carbonic anhydrase (CAs, EC 4.2.1.1) inhibitory activity against the human (h) isozymes I, II, and VII (cytosolic, off-target isoforms), and IX and XII (anticancer drug targets). Generally, CA I was not effectively inhibited, whereas effective inhibitors were identified against both CAs II (KIs in the range of 5.2-233 nM) and VII (KIs in the range of 2.3-350 nM). Nonetheless, CAs IX and XII were the most susceptible isoforms to this class of inhibitors. In particular, compounds bearing an unsubstituted phenyl ring at the pyrazoline 3 position showed 1.3-1.5 nM KIs against CA IX. In contrast, a subset of derivatives having a 4-halo-phenyl at the same position of the aromatic scaffold even reached subnanomolar KIs against CA XII (0.62-0.99 nM). Docking studies with CA IX and XII were used to shed light on the derivative binding mode driving the preferential inhibition of the tumor-associated CAs. The identified potent and selective CA IX/XII inhibitors are of interest as leads for the development of new anticancer strategies.

Intermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis

An efficient and versatile oxidative coupling reaction was developed for the synthesis of valuable β-functionalized unsaturated ketones and meta-substituted phenols. In the case of intramolecular reactions, achieving rapid molecular complexity through multiple dehydrogenative couplings is already a well-established strategy. Herein, we report an intermolecular multiple dehydrogenative coupling between ketones and nucleophilic amines or boronic acids using inexpensive copper(I) oxide as a catalyst. This method provides a facile access to highly desirable chemical products such as α,β-unsaturated ketones, enaminones, and synthetically relevant meta-substituted phenols. (Figure presented.).

Alpha, beta unsaturated ketone compound and preparation method and application thereof

The invention belongs to the technical field of organic synthesis, and in particular relates to an alpha, beta unsaturated ketone compound and a preparation method and application thereof. The methodcomprises the following steps: dissolving a compound of

Synthesis and photochemical transformations of a few olefin-appended 11,12-dibenzoyldibenzobarrelenes

Several olefin-appended dibenzobarrelenes have been synthesised by Diels-Alder reaction between 9-alkenylanthracenes and dibenzoylacetylene under carefully controlled conditions and their photochemistry was examined. Olefin appendages acted as efficient quenchers of the triplet state of these barrelenes.

Chiral octahedral complexes of Co(iii) as catalysts for asymmetric epoxidation of chalcones under phase transfer conditions

Stereochemically inert and positively charged chiral complexes of Co(iii) were shown to catalyze the asymmetric epoxidation of chalcones with H2O2 under phase transfer conditions. The reaction products had enantiomeric purities of up to 55%. It was also shown that complex 1a I- catalyzed the coupling reaction of a resulting epoxide with CO2 (conversion 72%).

Cooperative assembly of binary molecular components into tubular structures for multiple photonic applications

Take the tube: Tubular structures can be fabricated by the cooperative self-assembly of the binary molecular components TPI and APO (see picture). This method can also be used to make a single binary tube capable of performing multiple photonic functions,

Synthesis and biological evaluation of aromatic enones related to curcumin

Curcumin, a natural product isolated from the spice turmeric, has been shown to exhibit a wide range of pharmacological activities including certain anti-cancer properties. It has been specifically shown to be an effective inhibitor of angiogenesis both in vitro and in vivo. Using curcumin as a lead compound for anti-angiogenic analog design, a series of structurally related compounds utilizing a substituted chalcone backbone have been synthesized and tested via an established SVR cell proliferation assay. The results have yielded a wide range of compounds that equal or exceed curcumin's ability to inhibit endothelial cell growth in vitro. Due to both their commercial availability and their fairly straightforward synthetic preparation, these low molecular weight compounds are attractive leads for developing future angiogenic inhibitors.

PHOTOCHEMISTRY OF THE ANTHRACENE CHROMOPHORE: NOVEL ISOMERIZATION OF 1-(9-ANTHRYL)-2-BENZOYLETHYLENES

Photoexcited cis-1-(9-anthryl)-2-benzoylethylenes undergo a novel type of isomerization by skeletal rearrangement to give furano-annelated 5H-dibenzocycloheptenes.