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53757-54-3Relevant academic research and scientific papers
Enantiomers of Diastereomeric cis-N--N-phenylpropanamides: Synthesis, X-ray Analysis, and Biological Activities
Brine, George A.,Stark, Peter A.,Liu, Young,Carrol, F. Ivy,Singh, P.,et al.
, p. 1547 - 1557 (2007/10/02)
(+/-)-cis-N--N-phenylpropanamide (1) is a mixture of four stereoisomers , which together constitute two diastereoisomeric pairs of optical i
Stereoisomers of N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N- phenylpropanamide: Synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics
Wang,Zhu,Jin,Chen,Chen,Ji,Chi
, p. 3652 - 3659 (2007/10/03)
N-[1-(2-Hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanamide (ohmefentanyl, 1) is an extremely potent analgesic agent with high affinity and selectivity for opioid μ receptors. There are three chiral carbons in 1, so eight optically active iso
Probes for Narcotic Receptor Mediated Phenomena. 15. (3S,4S)-(+)-trans-3-Methylfentanyl Isothiocyanate, a Potent Site-Directed Acylating Agent for the δ Opioid Receptors in Vitro
Kim, Chong-Ho,Rothman, Richard B.,Jacobson, Arthur E.,Mattson, Mariena V.,Bykov, Victor,et al.
, p. 1392 - 1398 (2007/10/02)
Recently we reported the synthesis of the first enantiomeric pair of irreversible opioid ligands and specific interaction of the latter with the δ receptor.Here we report another enantiomeric pair of irreversi