537674-17-2Relevant academic research and scientific papers
Synthesis of potentially anti-inflammatory IPL576,092-contignasterol and IPL576,092-manoalide hybrids
Izzo, Irene,Avallone, Elvira,Della Monica, Carmela,Casapullo, Agostino,Amigo, Maria,De Riccardis, Francesco
, p. 5587 - 5593 (2007/10/03)
The synthesis of two potentially anti-inflammatory steroidal hybrid compounds has been accomplished through a 16- and 17-step sequence, respectively, starting from commercially available androst-5-en-3β-ol-17- one. The synthetic strategies are based both
Synthesis of a transmembrane ionophore based on a C2-symmetric polyhydroxysteroid derivative
Di Filippo, Marcello,Izzo, Irene,Savignano, Loredana,Tecilla, Paolo,De Riccardis, Francesco
, p. 1711 - 1717 (2007/10/03)
The synthesis of the C2-symmetric bis-(20S)-5α-23,24-bisnorchol-16-en-3β,6α,7β-triol-22- terephthaloate (1), active as Na+-transporting transmembrane channel, has been achieved in 16 steps (10% overall yield) starting from the commercially available androst-5-en-3β-ol-17-one (3). The straightforward stereospecific functionalization of the side-chain, via the 'ene' reaction, and the successful regioselective terephthaloylation of the C-22 hydroxy group, illustrate the efficiency of the synthetic strategy.
