537674-13-8Relevant academic research and scientific papers
SHIP1 MODULATORS AND METHODS RELATED THERETO
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Page/Page column 83; 84, (2014/10/15)
Compounds of formula (II): wherein A, R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.
Synthesis of a transmembrane ionophore based on a C2-symmetric polyhydroxysteroid derivative
Di Filippo, Marcello,Izzo, Irene,Savignano, Loredana,Tecilla, Paolo,De Riccardis, Francesco
, p. 1711 - 1717 (2007/10/03)
The synthesis of the C2-symmetric bis-(20S)-5α-23,24-bisnorchol-16-en-3β,6α,7β-triol-22- terephthaloate (1), active as Na+-transporting transmembrane channel, has been achieved in 16 steps (10% overall yield) starting from the commercially available androst-5-en-3β-ol-17-one (3). The straightforward stereospecific functionalization of the side-chain, via the 'ene' reaction, and the successful regioselective terephthaloylation of the C-22 hydroxy group, illustrate the efficiency of the synthetic strategy.
