53773-76-5

Usage

Preparation

Preparation by reaction of propionyl chloride with 3-methylanisole in the presence of aluminium chloride in methylene chloride for 3 h at 0°, in carbon disulfide at r.t. for 24 h (52%) or by Friedel–Crafts acylation using samarium triiodide.

Upstream product

• 79-03-8 propionyl chloride 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 123-62-6 propionic acid anhydride 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 53773-75-4 1-(4-methoxy-2-methyl-phenyl)-propan-1-ol 
• 1207258-55-6 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole 
• 1207259-15-1 2-[4-(3,5-dimethyl-[1,2,4]triazol-1-yl)-5-methyl-2H-pyrazol-3-yloxy]-1-(4-methoxy-2-methyl-phenyl)-propan-1-one 
• 1207259-18-4 4-(7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2,6-dimethylpyrazolo[5,1,-b]oxazol-3-yl)-3-methylphenol 
• 1318780-35-6 3-(4-(difluoromethoxy)-2-methylphenyl)-7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2,6-dimethylpyrazolo[5,1-b]oxazole 
• 1609579-46-5 6-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-1,5-dimethylpyrimidin-2(1H)-one 
• 1609577-29-8 4-(4-(1-(tert-butyl)-4-methyl-1H-pyrazol-5-yl)-3-methylphenoxy)furo[3,2-c]pyridine 
• 2887-55-0 1-(4-hydroxy-2-methylphenyl)propan-1-one 
• 1609581-18-1 1-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]propan-1-one 
• 1609581-19-2 3-(dimethylamino)-1-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-2-methylprop-2-en-1-one 
• 121347-32-8 2-(hydroxyimino)-1-(4-methoxy-2-methylphenyl)propan-1-one 
• 1609259-36-0 1-(4-methoxy-2-methylphenyl)propane-1,2-dione 
• 1609259-37-1 6-(4-methoxy-2-methylphenyl)-5-methylpyrazin-2(1H)-one 
• 1609259-38-2 6-(4-methoxy-2-methylphenyl)-1,5-dimethylpyrazin-2(1H)-one 

Relevant academic research and scientific papers

HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS

The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes and intermediates for preparation of; and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced β- arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses.

Organic compounds

There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.

Catalytic Friedel-Crafts acylation of aromatic ethers using Sml3

10% mol Sml3 catalysed the Friedel-Crafts acylation of aromatic ethers by acyl chlorides in acetonitrile with the yields of 48-82%. Reactions of various substituted aromatic ethers with acyl chloride were studied. The structures of compounds were established by IR and 1H NMR. The main product obtained with anisole is the para-substituted compound with only a trace (3, a pattern repeated with the other aromatic ethers used.

Synthesis and activity of 2-methyl-3-aminopropiophenones as centrally acting muscle relaxants

Some novel 2-methyl-3-aminopropiophenones were synthesized and their centrally acting muscle relaxant activities were,evaluated for an inhibitory effect on the flexor reflex in rats. The structure-activity relationships are discussed. In this series 2-methyl-3-pyrrolidino-1-(4-trifluoromethylphenyl)-propan-1-one (28) showed significant centrally acting muscle relaxant activity. In addition, the activities of each enantiomer (28-(S) and (R)) were studied along with their acute toxicities. Compound 28-(R) was found to exhibit more potent activity and weaker acute toxicity than 28-(S). Accordingly, compound 28-(R) (NK433) is under development as a novel centrally acting muscle relaxant.