53830-54-9

Upstream product

• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 106-46-7 para-dichlorobenzene 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 952-92-1 1-Benzyl-1,4-dihydronicotinamide 
• 154345-70-7 [(4-Chloro-benzenesulfinyl)-phenyl-methylene]-triphenyl-λ⁵-phosphane 
• 18803-44-6 sodium p-chlorothiophenolate 
• 100-39-0 benzyl bromide 
• 53772-44-4 benzyloxydiphenylphosphine 
• 160480-19-3 benzyl 4-chlorophenyl sulfoxide 
• 106-54-7 p-Chlorothiophenol 
• 140-11-4 Benzyl acetate 
• 637-87-6 1-Chloro-4-iodobenzene 
• 100-53-8 phenylmethanethiol 
• 108-88-3 toluene 

Downstream Products

• 83768-35-8 α-chlorobenzyl 4-chlorophenyl sulfide 
• 106-54-7 p-Chlorothiophenol 
• 71512-68-0 methyl 1,2,4-tri-O-acetyl-6-O-benzyl-α-D-glucopyranoside 
• 18527-19-0 4-chlorophenylthioacetonitrile 
• 19133-55-2 4-(p-Chlorphenylthio)-naphthol-⁽¹⁾ 
• 52913-85-6 4-chlorophenyl 4′-hydroxyphenyl sulfide 
• 13343-26-5 phenyl p-chlorophenyl sulfide 
• 1204677-85-9 N-cyano-S-benzyl-S-(4-chlorophenyl)sulfilimine 
• 350-50-5 benzyl fluoride 
• 100944-69-2 sodium 5-chloro-1-<α-(4-chlorophenylsulfenyl)>benzyl-2-oxo-1,2,3,4-tetrahydropyrimidine-4-sulfonate 
• 83768-37-0 5-chloro-1-α-(4-chlorophenylsulfenyl)benzyl-2(1H)-pyrimidinone 
• 83768-36-9 5-chloro-2-α-(4-chlorophenylsulfenyl)benzyloxypyrimidine 
• 160480-19-3 benzyl 4-chlorophenyl sulfoxide 
• 7058-22-2 1-(benzylsulfonyl)-4-chlorobenzene 

Relevant academic research and scientific papers

Synthesis of benzyl thioether derivatives via N-heterocyclic carbene palladium(II)-catalyzed cross coupling of benzylammonium salts with thiophenols

A new route to benzyl thioether derivatives has been developed via the N-heterocyclic carbene palladium(II)-catalyzed cross coupling of benzylammonium salts with thiophenols. Under the optimal conditions, different benzylammonium salts could be well toler

Production of Alkyl Aryl Sulfides from Aromatic Disulfides and Alkyl Carboxylates via a Disilathiane–Disulfide Interchange Reaction

The results of this study show that disilathiane is an effective mediator in the synthesis of alkyl aryl sulfides with disulfides and alkyl carboxylates. Mechanistic studies suggest that disilathiane promotes cleavage of the sulfur–sulfur bond of disulfides to generate thiosilane as a key intermediate. Diselenides were also applicable to this transformation to produce the corresponding selenides.

Unusual Deoxidative Coupling Reaction of β-Sulfinyl Esters with Benzylic Trimethylammonium Salts

A KOH-promoted unusual deoxidative coupling reaction of β-sulfinyl esters with benzylic trimethylammonium salts to produce thioethers is discovered for the first time. If quaternary ammonium salts synthesized from enantiomerically enriched amines are adopted, highly enantiomerically enriched benzyl thioethers (>95-99% ee) with configurations opposite to those of the enantiomerically enriched amines are obtained.

Transition-Metal-Free and Base-Promoted Carbon-Heteroatom Bond Formation via C-N Cleavage of Benzyl Ammonium Salts

A facile and general method for constructing carbon-heteroatom (C-P, C-O, C-S, and C-N) bonds via C-N cleavage of benzyl ammonium salts under transition-metal-free conditions was reported. The combination of t-BuOK and 18-crown-6 enabled a wide range of substituted benzyl ammonium salts to couple readily with different kinds of heteroatom nucleophiles, i.e. hydrogen phosphoryl compounds, alcohols, thiols, and amines. Good functional group tolerance was demonstrated. The scale-up reaction and one-pot synthesis were also successfully performed.

Synthesis method of benzyl sulfide

At present, there are many sulfur-containing drugs used for treating various diseases in the market, such as antipsychotic drug chloropropylthiophene; and sulfide has a wide biological activity, and not only can be easily converted into other types of sul

Transition metal-free coupling reactions of benzylic trimethylammonium salts with di(hetero)aryl disulfides and diselenides

A new protocol was developed to synthesize (enantioenriched) thioethers and selenoethers from (chiral) benzylic trimethylammonium salts and di(hetero)aryl disulfides or diselenides. These syntheses were promoted by the presence of weak base and did not require the use of any transition metal, and resulted in the target products with good to excellent yields (72-94%). Using quaternary ammonium salts synthesized from enantiomerically enriched amines led to highly enantiopure benzylic thioethers and selenoethers (94-99% ee) with configurations reversed from those of their enantioenriched quaternary ammonium salts. This journal is

Photochemical, Metal-Free Sigmatropic Rearrangement Reactions of Sulfur Ylides

Sigmatropic rearrangement reactions constitute one of the most fundamental reactions of carbenes. While state-of-the-art synthetic methods require the use of expensive precious metal catalysts, the application of visible light for the photolysis of α-aryldiazoacetates is much less investigated and provides an operationally simple entry to carbenes under mild reaction conditions. Herein, we report on blue-light induced sigmatropic rearrangement reactions of sulfur compounds with α-aryldiazoacetates. This process, depending on the substitution pattern of the sulfide, opens up formal insertion reactions of carbenes into S?N, S?C, or C?H bonds.

Nanolayered cobalt-molybdenum sulphides (Co-Mo-S) catalyse borrowing hydrogen C-S bond formation reactions of thiols or H2S with alcohols

Nanolayered cobalt-molybdenum sulphide (Co-Mo-S) materials have been established as excellent catalysts for C-S bond construction. These catalysts allow for the preparation of a broad range of thioethers in good to excellent yields from structurally diverse thiols and readily available primary as well as secondary alcohols. Chemoselectivity in the presence of sensitive groups such as double bonds, nitriles, carboxylic esters and halogens has been demonstrated. It is also shown that the reaction takes place through a hydrogen-autotransfer (borrowing hydrogen) mechanism that involves Co-Mo-S-mediated dehydrogenation and hydrogenation reactions. A novel catalytic protocol based on the thioetherification of alcohols with hydrogen sulphide (H2S) to furnish symmetrical thioethers has also been developed using these earth-abundant metal-based sulphide catalysts.

Oxidation of Organosulfides to Organosulfones with Trifluoromethyl 3-Oxo-1λ 3,2-benziodoxole-1(3 H)-carboxylate as an Oxidant

An alternative approach is described for the oxidation of organosulfides to the corresponding organosulfones by using trifluoromethyl 3-oxo-1λ 3,2-benziodoxole-1(3 H)-carboxylate as an oxidant. The oxidation of the sulfides was performed by using 2.4 equivalents of the oxidant in refluxing acetonitrile. The oxidation products were isolated in good to excellent yields.

Eco-compatible three component strategies for C-S bond formation in thioether and S-aryl-carbamodithioate compounds catalyzed by copper(II) nanoparticles supported on modified AlPO4

One-pot and three components C-S bond formation reactions in thioethers and S-aryl-carbamodithioates have been catalyzed by a copper heterogeneous nano-catalyst supported on modified AlPO4 under different reaction conditions. The above-mentioned nano-catalyst has been characterized by various techniques such as SEM, TEM, AFM, XRD, FT-IR, UV–Vis, CV, BET, TGA, ICP and XPS spectrometry and its particle size was estimated to be between 60–110?nm. Finally, the reusability of the catalyst up to ten cycles without any significant leaching is one of the outstanding properties of the catalyst.