538335-99-8

Upstream product

• 71999-74-1 tert-butyl N-(2-chloroethyl)carbamate 
• 210962-75-7 3-hydroxy-4-iodobenzonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 140-88-5 ethyl acrylate 
• 210963-75-0 3-[2-(t-butoxycarbonylamino)ethoxy]-4-iodobenzonitrile 

Downstream Products

• 538336-03-7 ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate 
• 538336-04-8 ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate 
• 252261-63-5 ethyl 3-[2-[2-[(1-acetimidoyl-4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]propionate 
• 538336-01-5 ethyl 3-[2-[2-[4-(1-tert-butoxycarbonyl-4-piperidyloxy)benzoylamino]ethoxy]-4-cyanophenyl]acrylate 
• 1026523-08-9 ethyl 3-[2-[2-[4-(4-piperidyloxy)benzoylamino]ethoxy]-4-amidinophenyl]acrylate 
• 1026962-48-0 3-(4-carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-carbonyl)-amino]-ethoxy}-phenyl)-acrylic acid ethyl ester 
• 252261-67-9 ethyl 3-[2-[2-[1-(4-pyridyl)piperidine-4-carbonylamino]ethoxy]-4-amidinophenyl]propionate 

Relevant academic research and scientific papers

Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids

An inhibitor of factor Xa (fXa), the m-substituted benzamidine AXC1578 (1a), was structurally modified with the aim of increasing its potency. In particular, pyruvic acid and propionic acid substituents were incorporated into the P1 benzamidine moiety to

Benzamidine derivatives

Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.