5385-61-5

Upstream product

• 917-64-6 methyl magnesium iodide 
• 4131-03-7 bis(3,4-dimethoxyphenyl)methanone 
• 5355-95-3 2-chloro-1,1-bis-(3,4-dimethoxy-phenyl)-ethane 
• 28000-62-6 2-bromo-1,1-bis(3,4-dimethoxyphenyl)ethane 
• 73786-27-3 (1R,5S,7S,8R)-8-Bromo-7,8-bis-(3,4-dimethoxy-phenyl)-10-oxa-1-azonia-tricyclo[5.2.1.0^1,5]decane; bromide 
• 91-16-7 1,2-dimethoxybenzene 
• 127-17-3 2-oxo-propionic acid 
• 94762-80-8 2,3-bis(3,4-dimethoxyphenyl)butane-2,3-diol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 73786-25-1 2,3-bis(3,4-dimethoxyphenyl)-1,3-butadiene 
• 73786-26-2 isoxazolidine 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 2859-78-1 4-Bromoveratrole 

Downstream Products

• 124112-01-2 1,1-bis-(3,4-dimethoxy-phenyl)-2-(2-nitro-phenylselanyl)-ethene 
• 119641-44-0 1,1-bis-(3,4-dimethoxy-phenyl)-2,2-bis-(4-nitro-phenylazo)-ethene 
• 121657-60-1 1,1-bis-(3,4-dimethoxy-phenyl)-2,2-bis-(2,4-dinitro-phenylazo)-ethene 

Relevant academic research and scientific papers

Base-promoted addition of DMA with 1,1-diarylethylenes: Application to a total synthesis of (-)-sacidumlignan B

A base-promoted addition of DMA (N,N-dimethylacetamide) to 1,1-diarylethylenes has been developed, and it provides a new strategy for the synthesis of N,N-dimethyl-4,4-diarylbutanamides from 1,1-diarylethylenes at room temperature. This method allows us to achieve the goal of synthesizing (-)-sacidumlignan B, and provides simple operation and broad substrate scope by avoiding the use of transition metal catalysts.

Acid-mediated specific α,α-diarylation and α-monoarylation reactions of pyruvic acid with/without decarbonylation

Pyruvic acid (3) was found to be arylated chemoselectively at the α- ketocarbonyl carbon in P2O5-MsOH affording decarbonylative α,α-diarylated products 5, decarbonylative α-monoarylated compounds 6, or non- decarbonylative α,α-diarylated adducts 7 depending on the reactivity of arenes (4a-g), in contrast to Lewis acid-catalyzed reaction of its acid chloride (2).

SYNTHESIS OF dl-SEPTICINE

Cyloaddition reaction of 1-pyrroline 1-oxide with 2,3-bis(3,4-dimethoxyphenyl)butadiene proceeded regioselectively to give two stereoisomeric isoxazolidine derivatives, one of which was converted into septicine by three-step reactions.