55860-23-6

Basic information

• Product Name: 3-CHLORO-N-(2-METHOXYPHENYL)PROPANAMIDE
• Synonyms: 3-CHLORO-N-(2-METHOXYPHENYL)PROPANAMIDE;3-chloro-N-(2-methoxyphenyl)propanamide(SALTDATA: FREE);3-chloro-N-(2-methoxyphenyl)propionamide
• CAS NO: 55860-23-6
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.67
• Mol File: 55860-23-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 68 °C
• Boiling Point: 360.6°C at 760 mmHg
• Flash Point: 171.9°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 2.19E-05mmHg at 25°C
• Refractive Index: 1.563
• PKA: 13.57±0.70(Predicted)
• CAS DataBase Reference: 3-CHLORO-N-(2-METHOXYPHENYL)PROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-N-(2-METHOXYPHENYL)PROPANAMIDE(55860-23-6)
• EPA Substance Registry System: 3-CHLORO-N-(2-METHOXYPHENYL)PROPANAMIDE(55860-23-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 55860-23-6(Hazardous Substances Data)

Usage

Uses

3-Chloro-N-(2-methoxyphenyl)propanamide is an intermediate used in the synthesis of 8-Hydroxy-3,4-dihydro-2(1H)-quinolinone (H941405), which is used in the studies of salvianolic acid B metabolites. Aripiprazole Impurity 5.

InChI:InChI=1/C10H12ClNO2/c1-14-9-5-3-2-4-8(9)12-10(13)6-7-11/h2-5H,6-7H2,1H3,(H,12,13)

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 53899-19-7 3,4-dihydro-8-methoxy-2(1H)-quinolinone 

Relevant articles and documents

Synthesis of novel 3,4-dihydroquinolin-2(1H)-one guanidines as potential antihypertensive agents

Hydroxy-3,4-dihydroquinolin-2(1H)-ones (4a-c) were synthesized by intramolecular Friedel Craft alkylation of N-(methoxyphenyl)-3- chloropropionamides (3a-c), obtained by acylation of anisidine with chloropropionyl chloride. The hydroxy-3,4-dihydro quinolin-2(1H)- ones (4a-c) were treated with various dibromo alkanes under phase transfer catalyst conditions at room temperature to give bromoalkyloxy- 3,4-dihydroquinolin-2(1H)- ones (5a-l) which on further reaction with guanidine hydrochloride in dimethyl formamide afforded N-{4- [(2-oxo-1,2,3,4-tetrahydroquinolin-5-yl)oxy]alkyl} guanidines (6a-l). These compounds were synthesized as potential antihypertensive agents.

Synthesis and anticonvulsant activity of some ω-(1H-1-imidazolyl)-N- phenylalkanoic acid amide derivatives

In this study, 15 ω-(1H-imidazol-1-yl)-N-phenylacetamide, propionamide and butyramide derivatives having methoxyl, methyl, nitro and chloro in ortho position of N-phenyl ring or without any substituent have been realized by two-step synthesis. Their antic