53906-84-6

Usage

Uses

Used in Organic Synthesis:
2-bromo-1,3-dimethyl-5-nitrobenzene is used as a chemical intermediate for the synthesis of various organic compounds. Its reactive nature, due to the presence of the bromine atom and nitro group, makes it a valuable building block in the production of a wide range of organic molecules.
Used in Pharmaceutical Industry:
2-bromo-1,3-dimethyl-5-nitrobenzene is used as a precursor in the synthesis of pharmaceutical compounds. Its unique structure and reactivity allow for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-bromo-1,3-dimethyl-5-nitrobenzene is also used in the agrochemical industry for the synthesis of various agrochemical products. Its potential applications in this field include the development of new pesticides, herbicides, and other agricultural chemicals.

Upstream product

• 16947-63-0 2,6-dimethyl-4-nitroaniline 
• 195389-20-9 3-bromo-2,4-dimethyl-6-nitro-aniline 
• 4703-15-5 N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide 
• 294853-97-7 N-(4-amino-2,6-dimethylphenyl)-4-methylbenzenesulfonamide 
• 87-62-7 2,6-dimethylaniline 
• 2423-71-4 2,6-dimethyl-4-nitro phenol 
• 195383-84-7 acetic acid-(3-bromo-2,4-dimethyl-anilide) 
• 59557-90-3 4-bromo-3,5-dimethylaniline 
• 156740-78-2 2,6-dimethyl-4-nitrophenyl trifluoromethanesulphonate 
• 576-22-7 2-Bromo-m-xylene 
• 1073338-97-2 2-bromo-1,3-dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzene 

Downstream Products

• 59557-90-3 4-bromo-3,5-dimethylaniline 
• 347190-81-2 2,5-bis(2,6-dimethyl-4-nitrophenyl)furan 
• 347190-86-7 2,5-bis(4-amino-2,6-dimethylphenyl)furan 
• 347190-92-5 2,5-bis(2,6-dimethyl-4-N,N'-di-BOCguanidinophenyl)furan 
• 866787-37-3 2-bromo-1-(bromomethyl)-3-methyl-5-nitrobenzene 
• 685507-24-8 (2,6-dimethyl-4-nitrophenyl)phenylcyanomethane-d 
• 1425187-97-8 2,6-dimethyl-4-nitrophenyl (4'-nitrophenyl) sulfide 
• 114660-00-3 2,6-dimethyl-4-nitrophenyl (phenyl) sulfide 
• 1425187-94-5 2,6-dimethyl-4-nitrophenyl(phenyl)sulfoxide 
• 1425188-03-9 C₈H₈⁽¹⁸⁾FNO₂ 
• 1425187-95-6 2,6-dimethyl-4-nitrophenyl(4'-nitrophenyl)sulfoxide 

Relevant academic research and scientific papers

meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C?H Borylation

Herein, we report the meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C?H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes in a one-pot fashion. This protocol allows the synthesis of meta-nitrated arenes that are tedious to prepare or require multistep synthesis using the existing methods. The reaction tolerates a wide array of ortho/para-directing groups, such as ?F, ?Cl, ?Br, ?CH3, ?Et, ?iPr ?OCH3, and ?OCF3. It also provides regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives. The application of this method is demonstrated in the late-stage modification of complex molecules and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, we have shown that the nitro product obtained by this strategy can also be directly converted to the aniline or hindered amine through Baran's amination protocol.

No-carrier-added [18F]fluoroarenes from the radiofluorination of diaryl sulfoxides

No-carrier-added [18F]fluoroarenes were synthesized through the radiofluorination of diaryl sulfoxides with [18F]fluoride ion. Diaryl sulfoxides bearing a para electron-withdrawing substituent readily gave the corresponding 4-[18F]fluoroarenes in high RCYs. This process broadens the scope for preparing novel 18F-labeling synthons and PET radiotracers.

Glucagon Receptor Modulators

The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.

Glucagon Receptor Antagonists, Preparation and Therapeutic Uses

The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the in

Aryl sulfonamide and sulfonyl compounds as modulators of PPAR and methods of treating metabolic disorders

Aryl sulfonamide and sulfonyl compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.

Diphenylmethane derivatives

The invention relates to novel diphenylmethane derivatives, processes for their preparation and their use in medicaments, in particular for the indications of arteriosclerosis and hypercholesterolaemia.

PROTON TRANSFER REACTIONS BETWEEN ORTHO-METHYL SUBSTITUTED DERIVATIVES OF 4-NITROPHENYLPHENYLCYANOMETHANE AND NITROGEN BASES IN ACETONITRILE SOLVENT

Equilibrium constants, rate constants, primary deuterium isotope effects, and activation parameters have been measured for the proton transfer reactions in acetonitrile solvent of 4-nitrophenylphenylcyanomethane and 2-methyl-4-nitrophenylphenylcyanomethane with tetramethylguanidine base and for the reactions of 2-methyl-4-nitrophenylphenylcyanomethane and 2,6-dimethyl-4-nitrophenylphenylcaynomethane with 1,5-diazabicycloundec-7-ene base.Introduction of the ortho-methyl groups in the substrate molecule caused significant reductions in the equilibrium and the rate constants.The expected rise in the kinetic primary deuterium isotope effect was not observed when the first ortho-methyl group was introduced, but a 20percent increase did accompany the introduction of the second ortho-methyl group.Enthalpy of activation measurements indicated that there was no increase in the proton tunnelling contribution to the isotope effect when the amount of steric hindrance is increased with ortho-methyl groups.