4703-15-5

Basic information

• Product Name: N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide
• Synonyms: N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide;N-(p-Toluenesulfonyl)-2,6-dimethylaniline;NSC 97146;N-Tosyl-2,6-dimethylaniline;Benzenesulfonamide,N-(2,6-Dimethylphenyl-4-Methyl-
• CAS NO: 4703-15-5
• Molecular Formula: C₁₅H₁₇NO₂S
• Molecular Weight: 275.36598
• Mol File: 4703-15-5.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 404.9°Cat760mmHg
• Flash Point: 198.7°C
• Appearance: /
• Density: 1.211g/cm³
• Vapor Pressure: 9.14E-07mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide(4703-15-5)
• EPA Substance Registry System: N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide(4703-15-5)

Safety Data

• Hazardous Substances Data: 4703-15-5(Hazardous Substances Data)

Usage

General Description

N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide, also known as dimethylsulfamoyl toluene, is a chemical compound that is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a sulfonamide derivative with the molecular formula C14H17NO2S and a molar mass of 259.35 g/mol. The compound is characterized by its aromatic structure, with a sulfonamide and methyl group substitutions at different positions on the benzene ring. N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide has various applications in the pharmaceutical industry, including serving as an active ingredient in medications and as a precursor in the synthesis of other drug candidates.

InChI:InChI=1/C15H17NO2S/c1-11-7-9-14(10-8-11)19(17,18)16-15-12(2)5-4-6-13(15)3/h4-10,16H,1-3H3

Upstream product

• 4124-41-8 p-toluenesulfonylanhydride 
• 87-62-7 2,6-dimethylaniline 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 108-38-3 m-xylene 
• 6781-98-2 2,6-dimethyl-1-chlorobenzene 
• 98-59-9 p-toluenesulfonyl chloride 
• 100379-00-8 2,6-dimethylbenzene boronic acid 
• 70-55-3 toluene-4-sulfonamide 
• 26334-20-3 2,6-dimethylphenylazide 

Downstream Products

• 109597-89-9 toluene-4-sulfonic acid-(4-bromo-2,6-dimethyl-anilide) 
• 294853-97-7 N-(4-amino-2,6-dimethylphenyl)-4-methylbenzenesulfonamide 
• 67083-22-1 N-(2,6-dimethyl-4-nitrophenyl)-4-methylbenzenesulfonamide 
• 85802-74-0 N,2,6-trimethyl-4-nitroaniline 
• 67083-24-3 2-(diethylamino)-N-(2,6-dimethyl-4-nitrophenyl)acetamide 
• 67083-23-2 2-chloro-N-(2,6-dimethyl-4-nitrophenyl)acetamide 

Relevant articles and documents

Ligand-Controlled Regiodivergence for Catalytic Stereoselective Semireduction of Allenamides

Ligand-controlled regiodivergence has been developed for catalytic semireduction of allenamides with excellent chemo- and stereocontrol. This system also provides an example of catalytic regiodivergent semireduction of allenes for the first time. The divergence of the semireduction is enabled by ligand switch with the same palladium pre-catalyst under operationally simple and mild conditions. Monodentate ligand XPhos exclusively promotes selective 1,2-semireduction to afford allylic amides, while bidentate ligand BINAP completely switched the regioselectivity to 2,3-semireduction, producing (E)-enamide derivatives.

Conformational control of bis-urea self-assembled supramolecular pH switchable low-molecular-weight hydrogelators

We report the synthesis and investigation into the structure-property relationships of eight different low molecular weight hydrogelators based on a bisaromatic urea core unit, all of which form gels as the pH of the solution is lowered. The low molecular weight hydrogelators are functionalized with carboxylic acid moieties on one aromatic ring, and the other aromatic ring features a nitro functional group either in the meta- or paraposition relative to the urea linkage. Ortho-methyl substituents were installed on the aromatic rings to enforce a non-coplanar arrangement between the phenyl and urea moieties. Gel formation was triggered by the addition of a mineral acid or the ring-opening hydrolysis of glucono-δ-lactone. The low molecular weight hydrogelators were studied by a variety of analytical techniques, including NMR spectroscopy and rheology. In addition, their ability to uptake a dye, methylene blue, was determined by UV-vis spectroscopy. (Figure Presented)

Three-Component Ring-Opening Reactions of Cyclic Ethers, α-Diazo Esters, and Weak Nucleophiles under Metal-Free Conditions

A protocol for three-component reactions of cyclic ethers, α-diazo esters, and weak nitrogen, oxygen, carbon, and sulfur nucleophiles (pKa = 2.2-14.8) to afford a variety of structurally complex α-oxyalkylated esters is reported. These reactions involve intermolecular activation of the cyclic ether (present in excess) by the α-diazo ester to form an oxonium ylide under metal-free conditions, followed by ring opening by the nucleophile.