53907-46-3

Usage

Uses

1. Used in Pharmaceutical Industry:
Methyl 2-mercaptopropionate is used as an intermediate in the synthesis of potential antibacterial and antifungal agents. Its thiol group can be exploited to form disulfide bonds with other molecules, which can enhance the stability and activity of the resulting compounds. Additionally, the ester group can be hydrolyzed to generate the corresponding carboxylic acid, which may have improved biological activity or solubility.
2. Used in Chemical Synthesis:
Methyl 2-mercaptopropionate can be used as a building block in the synthesis of various organic compounds, such as thiols, sulfides, and disulfides. Its reactivity and functional groups make it a versatile starting material for the preparation of complex molecules with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.
3. Used in Analytical Chemistry:
Due to its strong and distinctive odor, methyl 2-mercaptopropionate can be used as a reference compound in the development and calibration of analytical methods for the detection and quantification of thiols and other volatile organic compounds. Its unique chemical properties can also be exploited in the design of sensors and detectors for specific applications.
4. Used in Research and Development:
Methyl 2-mercaptopropionate can serve as a valuable research tool for studying the reactivity and properties of thiols and esters. Its synthesis and subsequent reactions can provide insights into the mechanisms and pathways involved in the formation of various organic compounds, which can be useful for the development of new synthetic methods and strategies.

InChI:InChI=1/C4H8O2S/c1-3(7)4(5)6-2/h3,7H,1-2H3

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 195989-29-8 Bromo-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acetonitrile 
• 67-56-1 methanol 
• 79-42-5 2-mercaptopropanoic acid 
• 1263098-83-4 2-acetylsulfanylpropionic acid methyl ester 
• 112-60-7 Tetraethylene glycol 
• 107-21-1 ethylene glycol 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 132907-12-1 (+/-)-trans-2-(4-chlorophenyl)-3,5-dimethylthiazolidin-4-one 
• 132907-12-1 (+/-)-cis-2-(4-chlorophenyl)-3,5-dimethylthiazolidin-4-one 
• 4131-74-2 Dimethyl 3,3'-thiodipropionate 
• 119383-02-7 (-)-trans-3,5-dimethyl-2-(pyridin-3-yl)-thiazolidin-4-one 
• 119383-03-8 (2R,5R)-(+)-trans-3,5-Dimethyl-2-(3-pyridyl)thiazolidin-4-one 
• 119383-00-5 (2R,5S)-(+)-cis-3,5-Dimethyl-2-(3-pyridyl)thiazolidin-4-one 
• 1259991-71-3 [2-(4-methoxyphenyl)-5-methyl-4-oxothiazolidin-3-yl]methylphosphonic acid 
• 1259991-73-5 2-(5-methyl-4-oxo-2-phenylthiazolidin-3-yl)ethylphosphonic acid 
• 1259991-75-7 3-[2-(4-chlorophenyl)-5-methyl-4-oxothiazolidin-3-yl]propylphosphonic acid 
• 7028-57-1 2-methyl-3,4-dihydro-3-oxo-2H-1,4-benzothiazine 
• 70400-90-7 3-cyclohexyl-2-cyclohexylimino-5-methyl-thiazolidin-4-one 
• 95421-57-1 ethyl 3-carbethoxy-4-hydroxy-5-methylthiophene-2-acetate 
• 119383-00-5 (+/-)-cis-3,5-Dimethyl-2-(3-pyridyl)thiazolidin-4-one 
• 119383-00-5 (+/-)-trans-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one 

Relevant academic research and scientific papers

Synthesis of 2-[Mercapto(cyano)methylene]-1,2,3,4-tetrahydroquinazolin-4-ones and 2-Amino-4-methylpyrazolo-[1,5-a]quinazolin-5(4H)-one

A series of 2-[mercapto(cyano)methylene]-1,2,3,4-tetrahydroquinazolin-4-ones and 2-amino-4-methylpyrazolo[1,5-a]quinazolin-5(4H)-one were prepared from 2-cyanomethylquinazolin-4(3H)-ones via α-bromo derivatives 4 and amide oxime 8, respectively. The new compounds have been characterized by elemental analyses and 1H-nmr, in some cases by ir and 13C-nmr investigations.

A composition and use thereof (by machine translation)

The invention discloses a composition and its application. The composition comprises: 1) mercapto compounds and ethylene multi-amine compound obtained by reaction of the product; and 2) mercapto compounds and ethylene multi-amine compounds to at least one. Tests show that: both the first containing mercapto compound with the multi-ethylene multi-amine compounds formed by the reaction of amide derivatives (composition) or added directly to the containing mercapto compound with the multi-ethylene multi-amine compounds have the amino compound on the Fmoc protecting group of with very rapid removal rate, and which can rapidly remove Fmoc protecting group formed of the arrest of the by-product [...], effectively improved [...] clearance rate, at the same time the composition with the addition of the [...] form has very good water-soluble, by simple washing can be by-product removal, thus obtaining high-purity amino compound. (by machine translation)

Transformation of the bromine end group into thiol in (Meth)acrylic polymers synthesized by atom transfer radical polymerization

The halogen end group of polymers prepared via atom transfer radical polymerization (ATRP) can be converted into other functional groups by different chemical modifications. Herein, a new method to modify the bromine end group into a thiol functionality in (meth)acrylic polymers synthesized by ATRP is reported for the first time. Thus, the bromine end group of several poly(methyl methacrylate)s was successfully converted into a thioacetate and then in a mercapto group by a controlled hydrolysis. This end-functionalization was confirmed introducing in situ a fluorescent group by thiol-ene "click" reaction with a synthetic alquene tethered to a 4,4-difluoro-4-bora-3a,4a- diaza-s-indacene (BODIPY) fragment. In addition, two model reactions in which bromide ATRP initiators were transformed into new thiol-functionalized molecules proved that this methodology can be applied to either methacrylic or acrylic polymers synthesized by ATRP.

Method for preparing mercaptopropionic acid esters

A process is provided for the preparation of mercaptopropionic acid esters by reaction of an acrylic acid ester with hydrogen sulfide in the presence of a weakly basic amine as a catalyst, a polyether as a co-catalyst, a polythiodipropionic acid ester as a reactive solvent, and added elemental sulfur.