53907-46-3Relevant articles and documents
Synthesis of 2-[Mercapto(cyano)methylene]-1,2,3,4-tetrahydroquinazolin-4-ones and 2-Amino-4-methylpyrazolo-[1,5-a]quinazolin-5(4H)-one
Fleischer, Judit,Takacs, Kalman,Hermecz, Istvan
, p. 1251 - 1254 (1997)
A series of 2-[mercapto(cyano)methylene]-1,2,3,4-tetrahydroquinazolin-4-ones and 2-amino-4-methylpyrazolo[1,5-a]quinazolin-5(4H)-one were prepared from 2-cyanomethylquinazolin-4(3H)-ones via α-bromo derivatives 4 and amide oxime 8, respectively. The new compounds have been characterized by elemental analyses and 1H-nmr, in some cases by ir and 13C-nmr investigations.
Transformation of the bromine end group into thiol in (Meth)acrylic polymers synthesized by atom transfer radical polymerization
Liras,Garcia,Quijada-Garrido,Paris
experimental part, p. 1335 - 1339 (2011/10/05)
The halogen end group of polymers prepared via atom transfer radical polymerization (ATRP) can be converted into other functional groups by different chemical modifications. Herein, a new method to modify the bromine end group into a thiol functionality in (meth)acrylic polymers synthesized by ATRP is reported for the first time. Thus, the bromine end group of several poly(methyl methacrylate)s was successfully converted into a thioacetate and then in a mercapto group by a controlled hydrolysis. This end-functionalization was confirmed introducing in situ a fluorescent group by thiol-ene "click" reaction with a synthetic alquene tethered to a 4,4-difluoro-4-bora-3a,4a- diaza-s-indacene (BODIPY) fragment. In addition, two model reactions in which bromide ATRP initiators were transformed into new thiol-functionalized molecules proved that this methodology can be applied to either methacrylic or acrylic polymers synthesized by ATRP.
