5394-85-4

Usage

Uses

Used in Pharmaceutical Industry:
(5Z)-5-[(1,3-benzodioxol-5-ylamino)methylidene]-1-(2,5-dimethoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione is used as a potential pharmaceutical agent for its possible pharmacological activities. Its unique chemical structure suggests that it could be developed into a drug candidate for treating various diseases or conditions, pending further research and development.
Used in Research Applications:
In the field of scientific research, (5Z)-5-[(1,3-benzodioxol-5-ylamino)methylidene]-1-(2,5-dimethoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione serves as a valuable compound for studying the properties and mechanisms of pyrimidine derivatives. It can be utilized in experiments to explore its potential interactions with biological targets, its effects on cellular processes, and its overall potential as a therapeutic agent.

Upstream product

• 105-53-3 diethyl malonate 
• 4192-77-2 ethyl cinnamate 
• 103-36-6 ethyl 3-phenyl-2-propenoate 

Downstream Products

• 82751-14-2 2-Ethoxycarbonyl-2-methylsulfanyl-3-phenyl-pentanedioic acid diethyl ester 
• 188670-37-3 7-Bromo-2-methyl-5-phenyl-heptanoic acid ethyl ester 
• 188670-33-9 7-Hydroxy-2-methyl-5-phenyl-heptanoic acid ethyl ester 
• 4160-80-9 3-phenylglutaric acid anhydride 
• 61198-49-0 4-phenyltetrahydropyran-2-one 
• 4165-96-2 3-phenylglutaric acid 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 105-53-3 diethyl malonate 

Relevant academic research and scientific papers

Folding strain stereocontrol in cyclohexane ring formation by means of an intramolecular ester enolate alkylation reaction

Diastereoselectivity in the cyclization of ethyl 7-bromo-2-methylheptanoates with an additional substituent at various positions in the chain, by LDA treatment, was investigated in connection with the concept of folding strain stereocontrol. Cyclization of 3-, 4-, and 6-methyl-substituted substrates revealed high selectivity, which demonstrates the prevalence of folding strain stereocontrol and the usefulness of this approach for stereoselective ring construction. In particular, reactions of the latter two substrates resulted in the stereodivergent preparation of diastereomeric 1,3-dimethylcyclohexanecarboxylates. In the case of the 5-methyl-substituted substrate, the selectivity of ring closure was only moderate. 1H and 13C NMR spectroscopic data were useful for determining the conformation of 1-methylcyclohexanecarboxylate derivatives. The origin of the diastereoselectivity was examined through the qualitative comparison of the strain in the diastereomeric folding in the transition state. Various factors that might affect stereoselectivity were examined in the cyclization of 5-substituted substrates to better understand this concept. As predicted, the selectivity increased as the substituent became bulkier: Ph Me ≈ Et ≤ i-Pr t-Bu. The effects of other factors - solvent, base counter cation, and leaving group - on selectivity agree with results predicted from the reactivity-selectivity relationship.