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Usage

Uses

Used in Pharmaceutical Industry:
N-methylpiperidine-2-carboxamide serves as a crucial building block for the synthesis of a variety of drugs. Its unique structure allows it to be incorporated into the development of new medicinal compounds, enhancing their efficacy and selectivity.
Used as a Chiral Auxiliary:
In the field of asymmetric synthesis, N-methylpiperidine-2-carboxamide is utilized as a chiral auxiliary. This application is vital for the production of enantiomerically pure compounds, which are essential in pharmaceuticals, as different enantiomers can have distinct biological activities and effects.
Used in Chronic Pain Management:
Research into N-methylpiperidine-2-carboxamide has indicated its potential use in the treatment of chronic pain. By modulating the nervous system's response to pain signals, N-methylpiperidine-2-carboxamide may offer a novel approach to managing persistent pain conditions.
Used in Opioid Dependence Treatment:
N-methylpiperidine-2-carboxamide has also been studied for its potential role in treating opioid dependence. Its interaction with opioid receptors could provide a pathway to alleviate withdrawal symptoms and support recovery from opioid addiction.

Upstream product

• 74-89-5 methylamine 
• 15862-72-3 ethyl pipecolate 
• 32559-18-5 methyl piperidine-2-carboxylate hydrochloride 
• 28697-07-6 N-benzyloxycarbonyl D/L-pipecolinic acid 
• 100222-58-0 Tetrahydro-oxazolo[3,4-a]pyridine-1,3-dione 

Downstream Products

• 195247-63-3 1-Benzyl-piperidine-2-carboxylic acid methylamide 

Relevant academic research and scientific papers

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

The highly stereoselective formation of pipecolic acid N-oxide and related derivatives

N-Alkylated derivatives of pipecolic acid are shown to undergo highly stereoselective oxidation to give stable tertiary amine N-oxides. The ester derivatives show a high degree of stability compared to their proline analogues.

ENANTIOMERIC QUANTIFICATIONS OF AMINO ACIDS THROUGH THEIR Nα-ACYL AMIDES BY GAS CHROMATOGRAPHY.

Apparent separation of 1.1 or higher on Chiralsil Val III can be obtained for Nα-acyl N-alkyl aminoacid amides allowing the use of short capillary gas chromatographic columns.A clean derivatization protocol without racemization is described, proceding through the NCA derivatives that are prepared from "in situ" silylated amino acids with trimethylsilyl cyanide.