53944-31-3

Basic information

• Product Name: 7-ethyl-5H-chroMeno[2,3-b]pyridin-5-one
• Synonyms: 7-ethyl-5H-chroMeno[2,3-b]pyridin-5-one;7-Ethyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine
• CAS NO: 53944-31-3
• Molecular Formula: C14H11NO2
• Molecular Weight: 225.24264
• Product Categories: Aromatics, Heterocycles, Miscellaneous Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 53944-31-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 7-ethyl-5H-chroMeno[2,3-b]pyridin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-ethyl-5H-chroMeno[2,3-b]pyridin-5-one(53944-31-3)
• EPA Substance Registry System: 7-ethyl-5H-chroMeno[2,3-b]pyridin-5-one(53944-31-3)

Safety Data

• Hazardous Substances Data: 53944-31-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-Ethyl-5H-chromeno[2,3-b]pyridin-5-one is used as a pharmaceutical compound for its antihistaminic and anaphylactic properties. It is particularly effective in treating allergic reactions and conditions such as histamine release, which can cause symptoms like itching, redness, and swelling. 7-ethyl-5H-chroMeno[2,3-b]pyridin-5-one's ability to inhibit histamine release makes it a valuable asset in the development of new drugs for allergy management.
Used in Chemical Research:
In addition to its pharmaceutical applications, 7-Ethyl-5H-chromeno[2,3-b]pyridin-5-one is also used in chemical research as a starting material for the synthesis of various other compounds. Its unique structure allows for further functionalization and modification, enabling the development of new molecules with potential applications in various fields, including materials science, agrochemistry, and environmental science.

Upstream product

• 50743-19-6 6-ethyl-4-oxo-4H-1-benzopyran-3-carbonitrile 
• 123-07-9 4-Ethylphenol 
• 2942-59-8 2-chloronicotinic acid 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 68301-76-8 2-amino-6-ethyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde 

Downstream Products

• 52549-17-4 2-(5h-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid 

Relevant articles and documents

pula Luo river fragrance synthetic method

The invention provides a synthetic method for pranoprofen and a novel compound structure which can be used for preparation of pranoprofen. More specifically, 2-chloronicotinic acid and paraethyl phenol are used as raw materials, and nucleophilic substitution, ring closure, halogenation, carbonyl group reduction, hydroxyl group elimination, a Grignard reaction and CO2 carbonyl group insertion are carried out so as to prepare pranoprofen.

A (RS)-2-(10-dihydro-9-oxa-1-nitrogen mixed anthracene -6-yl) propionic acid degradation method for synthesis of impurity

The invention relates to the technical field of organic compounds and particularly discloses a synthesis method for 7-ethyl-5-oxo-5H-[1]-benzopyran [2,3-b] pyridine which is an (RS)-2-(10-hydrogen-9-oxa-1-acridine-6-group) propionic acid degradation impurity. According to the method, the 7-ethyl-5-oxo-5H-[1]-benzopyran [2,3-b] pyridine is prepared by taking paraethyl phenol, 2-chloronicotinic acid and the like as raw materials through a Williamson reaction, a cyclization reaction and the like. The synthesis method disclosed by the invention has the advantages that the synthesis route is short, the raw materials can be simply and easily obtained, reaction conditions are mild, high temperature, high pressure or a special catalyst is not needed, the operation is simple, the yield is high, and the quality is stable. The synthesis method is suitable for volume production.

SYNTHESIS OF 3-SUBSTITUTED-5-OXO-5H-BENZOPYRANOPYRIDINE DERIVATIVES

3-Cyano-. 3-alkoxycarbonyl-, and 3-formyl-5-oxo-5H-benzopyranopyridine dervatives were prepared by reactions of 2-amino-4-oxo-4H-1-benzopyran-3-carboxaldehydes 1 with acetylene derivatives (methods A-C) or with reactive methylene compounds (methods D-E) and also by catalytic hydrogenation of 2-chloro-5-oxo-5H-benzopyranopyridine-3-carbonitriles 12 (method F).