53968-19-7

Upstream product

• 30709-67-2 2-amino-5-methyl-4-phenylthiazole 
• 79-04-9 chloroacetyl chloride 
• 93-55-0 1-phenyl-propan-1-one 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 

Downstream Products

• 105602-43-5 2-(N,N-diisopropylaminoacetamido)-4-phenyl-5-methylthiazole 
• 433305-70-5 2-(benzothiazol-2-ylthio)-N-(5-methyl-4-phenylthiazol-2-yl)acetamide 
• 105622-59-1 2-(N,N-diisopropylaminoacetamido)-4-phenyl-5-methylthiazole hydrochloride 
• 68558-01-0 2-(N,N-dipropylaminoacetamido)-4-phenyl-5-methylthiazole hydrochloride 
• 105602-42-4 N-(5-Methyl-4-phenyl-thiazol-2-yl)-2-morpholin-4-yl-acetamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 5-methyl-4-phenyl thiazole derivatives as anticancer agents

New N-(5-methyl-4-phenylthiazol-2-yl)-2-(substituted thio)acetamides were synthesized and studied for their anticancer activity. The title compounds were procured by reacting 2-chloro-N-(5-methyl-4-phenylthiazol-2-yl)acetamide with some mercapto derivatives. The structural elucidation of the compounds was performed by 1H-NMR, 13C-NMR and LC-MS/MS spectral data and elemental analyses. The synthesized compounds were investigated for their antitumor activities against A549 human lung adenocarcinoma cells and NIH/3T3 mouse embryoblast cell line for determining their selective cytotoxicity. 2-[(1-methyl-1H-tetrazol-5-yl)thio]-N-(5-methyl-4-phenylthiazol-2-yl)acetamide (4c) showed high selectivity, and whose IC50 value was determined as 23.30 ± 0.35 μM and >1000 μM against A549 human lung adenocarcinoma cells and NIH/3T3 mouse embryoblast cell lines, respectively. 2-[(1-Methyl-1H-imidazol-2-yl)thio]-N-(5-methyl-4-phenyl thiazol-2-yl)acetamide (4a) and 2-[(1-Methyl-1H-tetrazol-5-yl)thio]-N-(5-methyl-4-phenyl thiazol-2-yl)acetamide (4c) exhibited the highest apoptosis percentage among those tested, but not as high as the standard, cisplatin.