53979-19-4

Upstream product

• 851-36-5 diethyl (3,4-dimethoxybenzoyl)malonate 
• 1027047-55-7 veratryl tosylate 
• 105-53-3 diethyl malonate 
• 15818-13-0 diethyl 2-(3,4-dimethoxybenzylidene)malonate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 35227-78-2 diethyl (ethoxymagnesio)malonate 
• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 
• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 18066-68-7 ethyl 3,4-dimethoxyphenylacetate 
• 114855-49-1 diethyl α-bromo-3,4-dimethoxybenzylmalonate 

Downstream Products

• 112373-83-8 (R)-(E)-Diethyl 2-(3,4-dimethoxybenzyl)-2-<2-(p-toluenesulfinyl)vinyl>malonate 
• 114855-49-1 diethyl α-bromo-3,4-dimethoxybenzylmalonate 
• 331964-67-1 2-(3,4-Dimethoxy-benzyl)-malonic acid 
• 152961-70-1 2-<(3,4-Dimethoxyphenyl)methyl>propane-1,3-diol 
• 154317-95-0 2-(3,4-Dimethoxy-benzyl)-malonic acid monoethyl ester 
• 205505-52-8 ethyl 2-(3,4-dimethoxyphenyl)methylacrylate 
• 205505-73-3 (S)-4-(3,4-Dimethoxy-benzyl)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 205505-83-5 (S)-3-(3,4-Dimethoxy-phenyl)-2-hydroxy-2-hydroxymethyl-1-(2-hydroxy-phenyl)-propan-1-one 
• 205505-68-6 (S)-4-(3,4-Dimethoxy-benzyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester 
• 205505-78-8 [(S)-4-(3,4-Dimethoxy-benzyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-[2-(2-methoxy-ethoxymethoxy)-phenyl]-methanone 
• 205505-60-8 (S)-3-(3,4-Dimethoxy-phenyl)-2-hydroxy-2-hydroxymethyl-propionic acid ethyl ester 
• 108102-77-8 (R)-4-(3,4-dimethoxybenzyl)dihydrofuran-2(3H)-one 
• 177328-19-7 (R)-3-<(3,4-Dimethoxyphenyl)methyl>-4-hydroxybutanenitrile 
• 152961-73-4 (R)-2-<(3,4-Dimethoxyphenyl)methyl>-3-hydroxypropyl acetate 

Relevant academic research and scientific papers

Synthetic method of Brazilane hematoxylin natural product Brazilane

The invention relates to a synthetic method of Brazilian hematoxylin natural product Brazilian, which comprises the following steps: carrying out acetic anhydride monoprotection, Mitsunobu reaction and Desmarin oxidation reaction on a diol compound, and c

Synthetic method of brazilin natural product (+)-Brazilin

The invention relates to a synthetic method of a brazilin natural product, namely (+)-Brazilin. According to the synthetic method, a compound 3,4-dimethoxybenzyl alcohol as shown in formula 1 is usedas an initial raw material and is subjected to a nucleophilic substitution reaction, a lithium aluminum hydride reduction reaction, a Lipase PS enzyme catalyzed desymmetry reaction and a Mitsunobu reaction a Dess-Martin oxidation reaction, a one-pot-process Prins/Friedel-Crafts cascade reaction under an acidic condition, and the like so as to synthesize the natural product (+)-Brazilin. Accordingto the invention, reagents used in the method are conventional chemical reagents, reaction conditions are mild, operation is easy, a rate is relatively high, reaction byproducts are few, and synthesissteps are greatly reduced, and therefore, synthesis cost is reduced to a large extent.

Total synthesis of (–)-brazilane via a lipase-catalyzed desymmetrisation reaction

Herein, we described the asymmetric total synthesis of (–)-brazilane, an optically active natural product. The key steps of this synthetic approach are a lipase-catalyzed desymmetrisation reaction of a prochiral diol using vinyl acetate to prepare a chira

Covalent Inhibition of Bacterial Urease by Bifunctional Catechol-Based Phosphonates and Phosphinates

In this study, a new class of bifunctional inhibitors of bacterial ureases, important molecular targets for antimicrobial therapies, was developed. The structures of the inhibitors consist of a combination of a phosphonate or (2-carboxyethyl)phosphinate functionality with a catechol-based fragment, which are designed for complexation of the catalytic nickel ions and covalent bonding with the thiol group of Cys322, respectively. Compounds with three types of frameworks, including β-3,4-dihydroxyphenyl-, α-3,4-dihydroxybenzyl-, and α-3,4-dihydroxybenzylidene-substituted derivatives, exhibited complex and varying structure-dependent kinetics of inhibition. Among irreversible binders, methyl β-(3,4-dihydroxyphenyl)-β-(2-carboxyethyl)phosphorylpropionate was observed to be a remarkably reactive inhibitor of Sporosarcina pasteurii urease (kinact/KI = 10 420 s-1 M-1). The high potential of this group of compounds was also confirmed in Proteus mirabilis whole-cell-based inhibition assays. Some compounds followed slow-binding and reversible kinetics, e.g., methyl β-(3,4-dihydroxyphenyl)-β-phosphonopropionate, with Ki? = 0.13 μM, and an atypical low dissociation rate (residence time τ = 205 min).

Preparation method of donepezil hydrochloride for treating Alzheimer's disease

The invention discloses a preparation method of donepezil hydrochloride for treating the Alzheimer's disease. The preparation method comprises the following steps: (1) mixing 3,4-dimethoxy benzaldehyde with diethyl malonate, thus preparing a mixture M1 co

Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.

BENZOPHENANTHRIDINES V. INVESTIGATION OF THE RODIONOV-SUVOROV SCHEME. SYNTHESIS OF 3,3-DIETHOXYCARBONYL-2-(3,4-DIMETHOXYPHENYL)-6,7-DIMETHOXY-1-TETRALONE

Triethyl 1,3-bis(3,4-dimethoxyphenyl)propane-1,2,2-tricarboxylate was synthesized by the alkylation of the lithium enolate of ethyl homoveratrate with α-bromo(3,4-dimethoxybenzyl)malonic ester.It was converted by intramolecular acylation, catalyzed by BF3