53985-54-9

Upstream product

• 328-87-0 2-chloro-5-(trifluoromethyl)benzonitrile 
• 79427-88-6 2-hydroxy-5-(trifluoromethyl)benzoic acid 

Downstream Products

• 913649-92-0 1-(2-(benzyloxy)-5-(trifluoromethyl)phenyl)ethanone 
• 54625-33-1 2-Benzyloxy-5-trifluoromethylbenzoic Acid Sodium Salt 
• 67127-41-7 2-hydroxy-N-(1⁽²⁾H-tetrazol-5-yl)-5-trifluoromethyl-benzamide 
• 67127-74-6 2-benzyloxy-N-(1⁽²⁾H-tetrazol-5-yl)-5-trifluoromethyl-benzamide 

Relevant academic research and scientific papers

5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy

We describe the discovery and optimization of 5-substituted-N-pyridazinylbenzamide derivatives as potent and selective LRRK2 inhibitors. Extensive SAR studies led to the identification of compounds 18 and 23, which demonstrated good in vitro pharmacokinetic profile and excellent selectivity over 140 other kinases. Both compounds demonstrated high unbound fractions in both blood and brain. Compound 18 proved to be brain penetrant, and the high unbound fraction of compound 18 in brain enabled its in vivo efficacy in CNS, wherein a significant inhibition of LRRK2 Ser935 phosphorylation was observed in rat brain following intravenous infusion at 5 mg/kg/h.

Benzamide derivatives

Benzamide derivatives of the formula:- STR1 wherein R1 represents a fluorine, chlorine or bromine atom, or an alkyl, alkoxy, alkylthio, alkylsulphonyl, alkanoylamino, alkylamino or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), an alkanoyl, alkoxycarbonyl, alkoxycarbonylamino or alkylcarbamoyl group containing from 2 to 6 carbon atoms, or a hydroxy, formyl, nitro, trifluoromethyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl or aroyl group, and n represents an integer 1, 2 or 3, are new compounds possessing pharmacological properties, in particular properties of value in the treatment of respiratory disorders manifested by the interaction of tissue-fixed antibodies with specific antigens.

Substituted benzoic acid hypolipemic agents

Polysubstituted benzoic acids, and their use in mammals as hypolipemic agents.