328-87-0

Usage

Uses

Used in Water Supply Systems:
2-CHLORO-5-(TRIFLUOROMETHYL)BENZONITRILE is used as a component in the production of a thermal coupler control system for water supply systems. This application helps regulate the temperature and flow of water, ensuring efficient and effective water management.
Used in Chemical Synthesis:
As a chemical compound, 2-CHLORO-5-(TRIFLUOROMETHYL)BENZONITRILE can be utilized in the synthesis of various other chemicals and materials. Its unique properties make it a valuable intermediate in the production of different compounds, contributing to the development of new products and technologies.
Used in Pharmaceutical Industry:
2-CHLORO-5-(TRIFLUOROMETHYL)BENZONITRILE may also find applications in the pharmaceutical industry, where it can be used as a building block for the development of new drugs or as a reagent in the synthesis of existing medications. Its specific chemical properties make it a promising candidate for further research and development in this field.
Used in Research and Development:
Due to its unique chemical structure, 2-CHLORO-5-(TRIFLUOROMETHYL)BENZONITRILE can be employed in research and development activities, particularly in the fields of organic chemistry and materials science. It can be used to study various chemical reactions and properties, leading to a better understanding of its potential applications and benefits.

InChI:InChI=1/C8H3ClF3N/c9-7-2-1-6(8(10,11)12)3-5(7)4-13/h1-3H

Upstream product

• 143-33-9 sodium cyanide 
• 121-50-6 3-amino-4-chlorobenzotrifluoride 
• 15996-78-8 2-chloro-5-(trifluoromethyl)benzylamine 
• 82386-89-8 2-chloro-5-(trifluoromethyl)benzaldehyde 

Downstream Products

• 50594-25-7 2-(4-Nitro-phenoxy)-5-trifluoromethyl-benzonitrile 
• 50594-40-6 2-(3-Methyl-4-nitro-phenoxy)-5-trifluoromethyl-benzonitrile 
• 50594-38-2 2-(3-Ethoxy-4-nitro-phenoxy)-5-trifluoromethyl-benzonitrile 
• 50594-39-3 2-(4-Nitro-3-propoxy-phenoxy)-5-trifluoromethyl-benzonitrile 
• 15996-78-8 2-chloro-5-(trifluoromethyl)benzylamine 
• 127667-08-7 2-[Cyano-(4-fluoro-phenyl)-methyl]-5-trifluoromethyl-benzonitrile 
• 127667-30-5 (2-cyano-4-(trifluoromethyl)phenyl)(4-fluorophenyl)methyl phenyl sulfone 
• 77795-61-0 <2-(2-cyano-4-trifluoromethylphenylthio)-4-fluorophenyl>acetic acid 
• 77795-60-9 <2-(2-aminocarbonyl-4-trifluoromethylphenylthio)-4-fluorophenyl>acetic acid 
• 116616-85-4 3-Amino-1-cyano-1-(4-fluoro-phenyl)-5-trifluoromethyl-1H-indene-2-carboxylic acid methyl ester 
• 24156-17-0 2-(m-methylbenzylthio)-5-trifluoromethylbenzoic acid 
• 24156-14-7 2-benzylthio-5-trifluoromethylbenzoic acid 
• 789-96-8 (2-chloro-5-(trifluoromethyl)phenyl)(phenyl)methanone 
• 657-06-7 2-chloro-5-trifluoromethylbenzoic acid 

Relevant academic research and scientific papers

Scale-up and safety evaluation of a sandmeyer reaction

A scale-up of a new process for the production of 2-chloro-5- trifluoromethyl-benzonitrile by a Sandmeyer reaction of 2-Chloro-5- trifluoromethylaniline with copper cyanide/sodium cyanide is described. To ensure a safe implementation, a safety evaluation of the process was carried out, which is described in the following. The new process gives a better working environment and better productivity due to shorter reaction time.

HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles

We report an efficient HCl·DMPU assisted one-pot conversion of aldehydes into nitriles. The use of HCl·DMPU as both an acidic source as well as a non-nucleophilic base constitutes an environmentally mild alternative for the preparation of nitriles. Our protocol proceeds smoothly without the use of toxic reagents and metal catalysts. Diverse functionalized aromatic, aliphatic and allylic aldehydes incorporating various functional groups were successfully converted to nitriles in excellent to quantitative yields. This protocol is characterized by a broad substrate scope, mild reaction conditions, and high scalability. This journal is

Synthesis of nitriles from amines using nanoscale Co3O4-based catalysts via sustainable aerobic oxidation

The selective oxidation of amines for the benign synthesis of nitriles under mild conditions is described. Key to success for this transformation is the application of reusable cobalt oxide-based nanocatalysts. The resulting nitriles constitute key precursors and central intermediates in organic synthesis.

"Nanorust"-catalyzed benign oxidation of amines for selective synthesis of nitriles

Organic nitriles constitute key precursors and central intermediates in organic synthesis. In addition, nitriles represent a versatile motif found in numerous medicinally and biologically important compounds. Generally, these nitriles are synthesized by traditional cyanation procedures using toxic cyanides. Herein, we report the selective and environmentally benign oxidative conversion of primary amines for the synthesis of structurally diverse aromatic, aliphatic and heterocyclic nitriles using a reusable "nanorust" (nanoscale Fe2O3)-based catalysts applying molecular oxygen.

Process for producing trifluoromethylbenzylamines

The invention relates to a process for producing a trifluotomethylbenzylamine represented by the following general formula (1), 1where each R independently represents a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, an alkyl group having a carbon atom number of 1-4, an alkoxy group having a carbon atom number of 1-4, an amino group, a hydroxyl group or a trifluoromethyl group, and n represents an integer from 0 to 4. The process includes hydrogenating a trifluoromethylbenzonitrile by hydrogen in an organic solvent in the presence of ammonia and a catalyst containing a platinum group element. This trifluoromethylbenzonitrile is represented by the following general formula (2), 2where R and n are defined as above. With this process, it is possible to obtain the trifluoromethylbenzylamine at an extremely high yield.

Process for producing trifluoromethylbenzylamines

The invention relates to a process for producing a trifluoromethylbenzylamine represented by the following general formula (1). This process includes hydrogenating a trifliuoromethylbenzonitrile represented by the following general formula (2) by hydrogen in an organic solvent in the presence of ammonia, using a Raney catalyst, where each R independently represents a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, an alkyl group having a carbon atom number of 1-4, an alkoxy group having a carbon atom number of 1-4, an amino group, a hydroxyl group or a trifluoromethyl group, and n represents an integer from 0 to 4, where R and n are defined as above. With this process, it is possible to obtain the trifluoromethylbenzylamine easily and inexpensively at an extremely high yield.