539856-46-7

Upstream product

• 100-39-0 benzyl bromide 
• 919535-10-7 1-(1,1-dimethylethyl)-2-methyl 5-[(3-chloro-2-propenyl)-(1,1-dimethylethoxy)carbonylamino]-4-iodo-7-(phenylmethoxy)indole-1,2-dicarboxylate 
• 919535-06-1 1-(1,1-dimethylethyl)-2-methyl 5-[[(1,1-dimethylethoxy)-carbonyl]amino]-4-iodo-7-(phenylmethoxy)indole-1,2-dicarboxylate 
• 757951-78-3 2-iodo-4-nitro-6-(phenylmethoxy)benzenamine 
• 25945-96-4 2-benzyloxy-4-nitro-phenylamine 
• 121-88-0 5-Nitro-2-aminophenol 
• 539856-42-3 methyl 7-(benzyloxy)-5-nitro-1H-indole-2-carboxylate 
• 539856-48-9 methyl 7-hydroxy-5-nitro-1H-indole-2-carboxylate 
• 539856-45-6 methyl (E/Z)-7-(benzyloxy)-4-bromo-1-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)(3'-chloroprop-2'-enyl)amino]indole-2-carboxylate 
• 539856-44-5 methyl 7-(benzyloxy)-4-bromo-1-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]indole-2-carboxylate 
• 539856-50-3 methyl 7-(benzyloxy)-1-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]indole-2-carboxylate 
• 539856-43-4 methyl 5-amino-7-(benzyloxy)-1-(tert-butoxycarbonyl)indole-2-carboxylate 
• 539856-49-0 1-(1,1-dimethylethyl)-2-methyl-5-nitro-6-(phenylmethoxy)-indole-1,2-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 539856-47-8 methyl (1R/S)-5-benzyloxy-1-(chloromethyl)-3-[(5,6,7-trimethoxyindole-2-yl)carbonyl]-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylate 
• 144667-38-9 methyl (1R/S)-1-(chloromethyl)-5-hydroxy-3-[(5,6,7-trimethoxyindole-2-yl)carbonyl]-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylate 

Relevant academic research and scientific papers

SYNTHESIS OF DUOCARMYCIN ANALOGUES

A novel Fmoc protected duocarmycin subunit of formula (I) and utilisation as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid phase peptide synthesis, and in particular a method for the production of novel i

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity

The duocarmycins are potent antitumor agents with potential for use in the development of antibody-drug conjugates (ADCs) as well as being clinical candidates in their own right. In this article, we describe the synthesis of a duocarmycin monomer (DSA) th

A concise and efficient synthesis of seco-duocarmycin SA

A short and efficient synthesis of seco-duocarmycin SA (3), a highly potent cytostatic agent and direct precursor of the natural product duocarmycin SA (1), has been achieved. Starting from commercially available 2-methoxy-4-nitroaniline (4) the synthetic