757951-78-3

Upstream product

• 25945-96-4 2-benzyloxy-4-nitro-phenylamine 
• 100-39-0 benzyl bromide 
• 121-88-0 5-Nitro-2-aminophenol 

Downstream Products

• 757951-79-4 C₁₅H₁₅IN₂O₇S₂ 
• 539856-42-3 methyl 7-(benzyloxy)-5-nitro-1H-indole-2-carboxylate 
• 539856-49-0 1-(1,1-dimethylethyl)-2-methyl-5-nitro-6-(phenylmethoxy)-indole-1,2-dicarboxylate 
• 539856-50-3 methyl 7-(benzyloxy)-1-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]indole-2-carboxylate 
• 919535-06-1 1-(1,1-dimethylethyl)-2-methyl 5-[[(1,1-dimethylethoxy)-carbonyl]amino]-4-iodo-7-(phenylmethoxy)indole-1,2-dicarboxylate 
• 919535-10-7 1-(1,1-dimethylethyl)-2-methyl 5-[(3-chloro-2-propenyl)-(1,1-dimethylethoxy)carbonylamino]-4-iodo-7-(phenylmethoxy)indole-1,2-dicarboxylate 
• 539856-46-7 3.6-bis(1,1-dimethylethyl)-2-methyl 8-(chloromethyl)-7,8-dihydro-4-(phenylmethoxy)benzo[1,2-b:4,3-b′]dipyrrole-2,3,6-tricarboxylate 
• 757951-83-0 methyl 7-benzyloxy-1-methanesulfonyl-5-(N-methoxycarbonylamino)-4-(1-propyn-3-ol)indole-2-carboxylate 
• 757951-84-1 7-benzyloxy-4-(3-hydroxy-propenyl)-1-methanesulfonyl-5-methoxycarbonylamino-1H-indole-2-carboxylic acid methyl ester 
• 757951-86-3 methyl 4-(benzyloxy)-3,7,8,9-tetrahydro-8-methanesulfonyloxy-6-(methoxycarbonyl)-6H-pyrrolo[3,2-f]quinoline-2-carboxylate 
• 757951-82-9 methyl 7-benzyloxy-4-iodo-1-methanesulfonyl-5-(N-methoxycarbonylamino)indole-2-carboxylate 

Relevant academic research and scientific papers

SYNTHESIS OF DUOCARMYCIN ANALOGUES

A novel Fmoc protected duocarmycin subunit of formula (I) and utilisation as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid phase peptide synthesis, and in particular a method for the production of novel i

Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit

The design, synthesis, and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) derivatives are detailed representing analogs of duocarmycin SA and yatakemycin containing an imidazole replacement for the fused pyrrole found in the DNA alkylation subunit.

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity

The duocarmycins are potent antitumor agents with potential for use in the development of antibody-drug conjugates (ADCs) as well as being clinical candidates in their own right. In this article, we describe the synthesis of a duocarmycin monomer (DSA) th

New synthetic method for indole-2-carboxylate and its application to the total synthesis of duocarmycin SA

(Equation Presented) The sequential coupling and cyclization reactions between aryl halides and methyl propiolate were investigated. The electron-withdrawing groups on the aromatic ring are essential for producing the methyl indole-2-carboxylate derivativ