5399-18-8

Basic information

• Product Name: Butanal, 2-ethyl-,oxiMe
• Synonyms: Butanal, 2-ethyl-,oxiMe;2-Ethylbutanal oxime;2-Ethylbutyraldoxime;NSC 1109;Butal, 2-ethyl-,oxiMe
• CAS NO: 5399-18-8
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• Mol File: 5399-18-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 179.7 °C at 760 mmHg
• Flash Point: 88.1 °C
• Appearance: /
• Density: 0.89 g/cm³
• Vapor Pressure: 0.435mmHg at 25°C
• Refractive Index: 1.435
• PKA: 11.21±0.40(Predicted)
• CAS DataBase Reference: Butanal, 2-ethyl-,oxiMe(CAS DataBase Reference)
• NIST Chemistry Reference: Butanal, 2-ethyl-,oxiMe(5399-18-8)
• EPA Substance Registry System: Butanal, 2-ethyl-,oxiMe(5399-18-8)

Safety Data

• Hazardous Substances Data: 5399-18-8(Hazardous Substances Data)

Usage

General Description

Butanal, 2-ethyl-, oxime is a chemical compound with the molecular formula C6H13NO. It is a colorless to light yellow liquid with a slightly unpleasant odor. This chemical is used as an intermediate in the production of various chemicals and as a stabilizer for rubber. It is also used in the manufacturing of pharmaceuticals, pesticides, and other organic compounds. Butanal, 2-ethyl-, oxime is known to be harmful if swallowed, inhaled, or absorbed through the skin, and it can cause irritation to the eyes, skin, and respiratory system. Therefore, it should be handled with care and in accordance with safety guidelines.

InChI:InChI=1/C6H13NO/c1-3-6(4-2)5-7-8/h5-6,8H,3-4H2,1-2H3/b7-5-

Upstream product

• 97-96-1 2-Ethylbutyraldehyde 
• 96-14-0 3-methylpentane 

Downstream Products

• 97-96-1 2-Ethylbutyraldehyde 
• 229613-93-8 (+)-methyl (3aR,4R,6S,6aS)-4-[(tert-butoxycarbonyl)-amino]-3-(1-ethylpropyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylate 
• 617-79-8 2-ethyl-N-butylamine 
• 54774-85-5 bis(2-ethylbutyl)amine 
• 617-80-1 2-ethyl-butyronitrile 

Relevant articles and documents

A novel synthetic approach to the racemic Neuraminidase inhibitor Peramivir

An advanced intermediate in the synthesis of the racemic Neuraminidase inhibitor Peramivir was synthesised in a new and versatile manner starting from a stereoselective 1,3-dipolar cycloaddition reaction between the nitrile oxide deriving from 2-ethylbutanal and the commercially available and inexpensive bicyclo[2.2.1]hepta-2,5-diene. The reaction mainly afforded the exo-isoxazolino-norbornene derivative from which the oxidative cleavage of the carbon[sbnd]carbon double bond followed by subsequent dehydration led to the corresponding anhydride intermediate. Amines and alcohols were used as nucleophiles for opening the anhydride, with amines providing the better results. Both the monoester–monoacid and the monoester–monoamide were transformed into the monoester–monoamino intermediate from which the synthesis continued using previously published methods. In the best protocol, the total yield of this key intermediate was increased up to 17% from bicyclo[2.2.1]hepta-2,5-diene.

(1S, 2S, 3S, 4R)-3-Y(1S)-1-ACETYLAMINO-2-ETHYL-BUTYL¨-4-GUANIDINO-2- HYDROXYL-CYCLOPENTYL-1-CARBOXYLIC ACID HYDRATES AND PHARMACEUTICAL USES THEREOF

The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.