53995-06-5Relevant academic research and scientific papers
Preparation and application of imidazolone compounds containing tetrahydroisoquinoline structure
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Paragraph 0023-0024, (2020/05/01)
The invention discloses imidazolone compounds containing a tetrahydroisoquinoline structure represented by figure 1, and an application of the imidazolone compounds as a novel protein arginine methyltransferase 5 inhibitor.
Synthesis of symmetrically and unsymmetrically substituted N,N′-diaryl-imidazolin-2-ones by copper-catalyzed arylamidation under microwave-assisted and conventional conditions
Hafner, Thomas,Kunz, Doris
, p. 1403 - 1411 (2008/02/13)
A convenient synthesis of unsymmetrically substituted N,N′- diarylimidazolin-2-ones is reported. Starting from 2,2-dimethoxyethylamine, the first aryl group was introduced by reaction with arylisocyanate and subsequent cyclization to afford N-arylimidazol
Lithiation of 1-arylimidazol-2(1H)-ones and 1-aryl-4,5-dihydroimidazol- 2(1H)-ones
Llopart, Carme Cantos,Ferrer, Conchita,Joule, John A.
, p. 1649 - 1661 (2007/10/03)
1-Arylimidazol-2(1H)-ones are shown to be readily lithiated, using 2 mol equiv. of n-butyllithium, on the benzene ring, ortho to the heterocycle. 1-Aryl-4,5-dihydroimidazol-2(1H)-ones also undergo metalation on the aromatic substitutuent ortho to the heterocycle, but less efficiently. 1-Aryl-3-methylimidazol-2(1H)-ones are lithiated on the heterocyclic ring and then on the benzene ring ortho to the heterocycle. No ortho-directing effect was found for 1-aryl-4,5-dihydro-3-methylimidazol-2(1H)-ones.
Compositions including and methods of using conformationally restricted 5-[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]imidazo[1,5-a]pyridine derivatives as angiotensin II antagonists.
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, (2008/06/13)
Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders.
NITROSOCHLORINATION REACTION OF SUBSTITUTED IMIDAZOLIN-2-ONES
Golovko, V. V.,Statsenskaya, A. I.,Baskakov, Yu. A.,Putsykin, Yu. G.
, p. 1084 - 1087 (2007/10/02)
Interaction of nitrosyl chloride with 1-arylimidazolin-2-ones in methanol leads to the formation of 4,5-dimethoxyimidazolidin-2-ones.Under similar conditions 1,5-diarylimidazolin-2-ones give 1,5-diaryl-4-oximino-5-alkoxyimidazolidin-2-ones.When the reacti
Effect of structural modification of the hydrantoin ring on anticonvulsant activity
Cortes,Liao,Watson,Kohn
, p. 601 - 606 (2007/10/02)
Selectively substituted hydantoins (15 examples), 4-hydroxy-2-imidazolidinones (13 examples), 2-imidazolones (10 examples), 2-imidazolidinones (four examples), vicinal diamines (two examples), and simple amino acid derivatives (four examples) have been pr
