1201-15-6

Upstream product

• 103-71-9 phenyl isocyanate 
• 928729-62-8 1-methyl-1-(2,2-dimethoxyethyl)-3-phenylurea 
• 62-53-3 aniline 
• 53995-05-4 N-Phenylcarbamoylaminoacetaldehyde dimethyl acetal 
• 53995-06-5 1-phenyl-1,3-dihydro-2H-imidazol-2-one 
• 74-88-4 methyl iodide 
• 74-89-5 methylamine 
• 33876-94-7 N-phenyl-1H-imidazole-1-carboxamide 

Downstream Products

• 1095319-49-5 5-(2,4-dihydroxy-3-methylphenyl)-1-methyl-3-phenylimidazolidin-2-one 
• 1095319-50-8 4-(2,3,4-trihydroxy-phenyl)-3-methyl-1-phenylimidazolidin-2-one 
• 16939-00-7 1-phenyl-3,4-dimethylimidazol-2(1H)-one 
• 392691-83-7 4-(3-methyl-2-oxoimidazolidin-1-yl)benzene-1-sulfonyl chloride 

Relevant academic research and scientific papers

Nucleophilic Cyclization/Electrophilic Substitution of (2,2-Dialkoxyethyl)ureas: Highly Regioselective Access to Novel 4-(Het)arylimidazolidinones and Benzo[ d[[1,3]diazepinones

Imidazolidin-2-one and 1,3-benzodiazepin-2-one scaffolds are structural motifs of many biologically active compounds. Herein, we report a highly regioselective acid-catalyzed intramolecular nucleophilic cyclization/intermolecular electrophilic substitutio

Reaction of resorcinol and its derivatives with urea acetals

Reaction of 2-methylresorcinol and pyrogallol with urea acetals of various structures was studied. Depending on the structure of the acetal used, reaction was established to result in eiter calix[4]resorcinols containing urea fragment or in imidazolidin-2

Reactions of resorcinol derivatives with 1-methyl-3-phenylimidazol-2-one as a new method for the synthesis of 5-arylimidazolidin-2-ones

Substituted imidazolidin-2-ones have been synthesised by the interaction of imidazol-2-one with 2-methylresorcinol and pyrogallol in a chloroform solution in the presence of trifluoroacetic acid.

Lithiation of 1-arylimidazol-2(1H)-ones and 1-aryl-4,5-dihydroimidazol- 2(1H)-ones

1-Arylimidazol-2(1H)-ones are shown to be readily lithiated, using 2 mol equiv. of n-butyllithium, on the benzene ring, ortho to the heterocycle. 1-Aryl-4,5-dihydroimidazol-2(1H)-ones also undergo metalation on the aromatic substitutuent ortho to the heterocycle, but less efficiently. 1-Aryl-3-methylimidazol-2(1H)-ones are lithiated on the heterocyclic ring and then on the benzene ring ortho to the heterocycle. No ortho-directing effect was found for 1-aryl-4,5-dihydro-3-methylimidazol-2(1H)-ones.

Efficient solid-phase synthesis of disubstituted 1,3-dihydro-imidazol-2- ones

A bromoacetal linker was used to achieve the synthesis of ureas on a solid support. The resulting ureido acetals were treated with TFA and were converted in an intramolecular cyclization via N-acyliminium ion to disubstituted 1,3-dihydro-imidazol-2-ones.

Substituted 2- (S) -hydroxy-3- (piperidin-4-yl-methylamino) -propyl ethers and substituted 2-aryl-2- (R) - hydroxy-1- (piperidin-4-yl-methyl) -ethylamine beta-3 adrenergic receptor agonists

This invention provides compounds of Formula I having the structure wherein A, B, Z, R and R1 are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.